Opposite Effects of Central Amygdaloid Vasopressin and Oxytocin on the Regulation of Conditioned Stress Responses in Male Rats
Opposite Effects of Central Amygdaloid Vasopressin and Oxytocin on the Regulation of Conditioned Stress Responses in Male Rats
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中央杏仁加压素和催产素对雄性大鼠条件应激反应调节的相反作用
DOI：
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发表时间：
1992
影响因子：
5.2
通讯作者：
B. Bohus
中科院分区：
文献类型：
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作者：
B. Roozendaal;G. Schoorlemmer;A. Wiersma;S. Sluyter;P. Driscoll;J. Koolhaas;B. Bohus
杏仁核的中央核（CEA）似乎在条件环境挑战期间选择性地参与行为（不动）和伴随的副交感神经反应（心动过缓）的被动成分，使条件交感神经、肾上腺髓质和肾上腺皮质反应不受影响（Roozendaal等人，准备中）。与迷走神经复合体和导水管周围灰质的强单突触肽能连接可能介导了这些作用。脑室内注射精氨酸-8-加压素（AVP）可增强这些应激诱导的心动过缓和不动反应。AVP可能通过CEA中的AVP和/或催产素（OT）感受系统发挥这些作用。将AVP（溶于1 μ l人工脑脊液）微量注入清醒雄性Wistar大鼠的CEA，可引起心率和行为的剂量依赖性变化：高剂量AVP（2ng）可引起心率和行为的一过性增加，而低剂量AVP（20和200 μ g）则无此作用。而且，在部分动物中，低剂量的AVP甚至引起相反的作用，即心动过缓。OT给药（2 ng）诱导的反应类似于高剂量AVP诱导的反应。AVP输注后，血浆去甲肾上腺素和肾上腺素均不受影响，表明心动过速是由于副交感神经控制减少，而不是交感神经流出的刺激。以雄性高回避型和低回避型罗曼犬为实验动物，研究了条件应激对AVP和OT的影响。(RLA)大鼠，选择穿梭箱收购行为的基因。在RLA大鼠中，对情绪应激的心脏和行为反应是心动过缓和不动，
The central nucleus of the amygdala (CEA) seems to be selectively involved in the passive component of the behavioral (immobility) and the accompanying parasympathetic response (bradycardia) during conditioned environmental challenges,' leaving conditioned sympathetic, adreno-medullary, and adreno-cortical responses unaffected (Roozendaal et al., in preparation). Robust monosynaptic, .peptidergic connections to the vagal complex and periaqueductal gray may be mediating these effects. Intracerebroventricularly administered arginine-8-vasopressin (AVP) potentiates these stress-induced bradycardiac and immobility responses.* AVP may exert these effects via AVP and/or oxytocin (OT) receptive systems in the CEA.' Microinfusion of AVP (dissolved in 1 p1 artificial CSF) into the CEA of conscious male Wistar rats under resting conditions, leads to a dose-dependent change in heart rate and behavior: A high dose of AVP (2 ng), but not lower ones (20 and 200 pg), causes a transient increase in heart rate and behavioral a~t iv i ty .~ Moreover, in a part of the animals, the low dose of AVP even causes an opposite effect, that is, bradycardia. OT administration (2 ng) induces responses similar to those induced with the high dose of AVP. Neither plasma norepinephrine nor epinephrine is influenced after AVP infusion, suggesting that the tachycardia is due to reduced parasympathetic control, rather than a stimulation of the sympathetic outflow. The effects of AVP and OT during conditioned stress were studied in male Roman high-avoidance (RHA) and Roman low-avoidance. (RLA) rats, selected genetically for shuttle-box acquisition behavior. In RLA rats the cardiac and behavioral responses to the emotional stressor are bradycardia and immobility,