Whitening of odor representations by the wiring diagram of the olfactory bulb
Whitening of odor representations by the wiring diagram of the olfactory bulb
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DOI：
10.1038/s41593-019-0576-z
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发表时间：
2020-01-20
影响因子：
25
通讯作者：
Friedrich, Rainer W.
中科院分区：
文献类型：
--
作者：
Wanner, Adrian A.;Friedrich, Rainer W.
作者测量了诱发活动，并对斑马鱼幼体的嗅球接线图进行了密集重建，揭示了白化机制，这是一种通过记忆网络对模式分类的活动进行去相关的计算。对这种计算的机械理解需要神经元网络的接线图。在这项研究中，我们研究了嗅球（OB）如何执行“白化”，这是一种基本的计算，可以使活动模式去相关，并支持记忆网络对其进行分类。我们测量了气味诱发的活动在OB的斑马鱼幼虫，随后重建完整的布线图，体积电子显微镜。由此产生的功能性连接体揭示了多突触连接基序的过度表达，这些基序介导具有相似调谐的神经元之间的相互抑制。这种连通性抑制了冗余响应，并且是必要的，也足以在模拟中重现白化。因此，气味表征的白化是由适应自然输入模式的接线图中的高阶结构介导的。
The authors measure evoked activity and perform dense reconstruction of the olfactory bulb wiring diagram in a zebrafish larva, uncovering a mechanism for whitening, a computation that decorrelates activity for pattern classification by memory networks.Neuronal computations underlying higher brain functions depend on synaptic interactions among specific neurons. A mechanistic understanding of such computations requires wiring diagrams of neuronal networks. In this study, we examined how the olfactory bulb (OB) performs 'whitening', a fundamental computation that decorrelates activity patterns and supports their classification by memory networks. We measured odor-evoked activity in the OB of a zebrafish larva and subsequently reconstructed the complete wiring diagram by volumetric electron microscopy. The resulting functional connectome revealed an over-representation of multisynaptic connectivity motifs that mediate reciprocal inhibition between neurons with similar tuning. This connectivity suppressed redundant responses and was necessary and sufficient to reproduce whitening in simulations. Whitening of odor representations is therefore mediated by higher-order structure in the wiring diagram that is adapted to natural input patterns.