Occupational pesticide exposure and adverse health effects at the clinical, hematological and biochemical level
Occupational pesticide exposure and adverse health effects at the clinical, hematological and biochemical level
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DOI：
10.1016/j.lfs.2015.10.013
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发表时间：
2016-01-15
期刊：
影响因子：
6.1
通讯作者：
Hernandez, Antonio F.
中科院分区：
文献类型：
--
作者：
Garcia-Garcia, Carmen R.;Parron, Tesifon;Hernandez, Antonio F.
目的：虽然流行病学研究调查了职业性农药接触与不同不良健康结果之间的关系，但很少在同一作物季节使用不同农药的两个时间点对个体进行评估。材料与方法：对西班牙东南部阿尔梅里亚海岸189名集约化农业劳动者和91名健康对照者的临床症状、体格检查指标、血清学和临床化学指标进行测定，评价农药暴露的潜在影响。主要发现：与对照相比，温室工人在高农药暴露期出现眼部和皮肤症状的风险增加（OR分别为4.80和2.87）；然而，在临床症状方面没有观察到差异。低暴露期心电图改变（OR: 3.35）和肺活量改变（OR: 5.02）的风险更大。在这两个时期，温室工人的红细胞乙酰胆碱酯酶明显低于对照。血液学参数的评估显示，与对照相比，温室工人的红细胞、白细胞、血小板和血红蛋白计数有所增加，并且在农药高暴露期与低暴露期也有所增加。临床化学参数的变化包括：与对照组相比，温室工人的葡萄糖、肌酐、总胆固醇、甘油三酯和碱性磷酸酶水平降低；然而，这些参数在农药高暴露期和低暴露期有所提高。意义：这些发现表明，在综合生产系统下，长期职业性暴露于毒性低于先前化合物的农药，会产生轻微的毒性作用，特别是针对皮肤和眼睛，以及未知长期后果的微妙亚临床（生化）变化。(C) 2015爱思唯尔公司版权所有。
Aims: Although epidemiological studies have investigated associations between occupational pesticide exposures and different adverse health outcomes, they have rarely assessed individuals at two time-points of a same crop season with different pesticide use.Material and methods: Clinical symptoms, physical examination signs, hematological and clinical chemistry parameters were measured in 189 intensive agriculture workers and 91 healthy control subjects from Almeria coastline (Southeastern Spain) to evaluate potential effects of pesticide exposure.Key findings: Greenhouse workers showed an increased risk of ocular and skin signs relative to controls at the period of high pesticide exposure (OR: 4.80 and 2.87, respectively); however, no differences were observed for clinical symptoms. A greater risk for ECG changes (OR: 3.35) and altered spirometry (OR: 5.02) was found at the period of low exposure. Erythrocyte acetylcholinesterase was significantly decreased in greenhouse workers relative to controls in both periods. Assessment of hematological parameters revealed increased counts of erythrocytes, leukocytes, platelets and hemoglobin in greenhouse workers relative to controls, and also in the period of high versus low pesticide exposure. Changes in clinical chemistry parameters included decreased levels of glucose, creatinine, total cholesterol, triglyceride and alkaline phosphatase in greenhouse workers relative to controls; however, these parameters were raised in the period of high versus low pesticide exposure.Significance: These findings suggest that chronic occupational exposure to pesticides of lower toxicity than former compounds under integrated production systems elicit mild toxic effects, particularly targeting the skin and eyes, as well as subtle subclinical (biochemical) changes of unknown long-term consequences. (C) 2015 Elsevier Inc. All rights reserved.