Increased mast cell degranulation within thalamus in early pre-lesion stages of an experimental model of Wernicke's encephalopathy.
Increased mast cell degranulation within thalamus in early pre-lesion stages of an experimental model of Wernicke's encephalopathy.
复制标题
在韦尼克脑病实验模型的早期病变前阶段，丘脑内肥大细胞脱颗粒增加。
DOI：
10.1097/00005072-199907000-00011
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发表时间：
1999
影响因子：
3.2
通讯作者：
Langlais,PJ
中科院分区：
文献类型：
--
作者：
Ferguson,M;Dalve-Endres,AM;McRee,RC;Langlais,PJ
硫胺素缺乏6-7天后，大鼠丘脑内肥大细胞脱颗粒的数量和百分比明显增加。在下橄榄核和前庭外侧核中未检测到肥大细胞，这些核也被TD严重破坏。TD后11-12天，丘脑中ED 2免疫阳性巨噬细胞数量增加。在脑干核中，巨噬细胞数量的增加在给药早期（即第6天）发生。丘脑内GFAP阳性星形胶质细胞的增加发生在肥大细胞的变化之后，巨噬细胞的增加之前。脑干中反应性星形胶质细胞沿着巨噬细胞的增多。这些数据表明，肥大细胞脱颗粒是一个非常早期的反应诱导TD，和由此产生的细胞因子和其他化学介质的释放可能发挥关键作用的早期血管损伤和最终的组织破坏内丘脑，但不是在脑干。这些结果也表明，巨噬细胞和反应性星形胶质细胞可能在脑干病变的发病机制中发挥更直接的作用。
A large increase in the number and percentage of degranulating mast cells was observed within thalamus of rats after 6–7 days of thiamine deficiency (TD). No mast cells were detected in the inferior olivary and lateral vestibular nuclei, which are also severely damaged by TD. After 11–12 days of TD, the number of ED2 immunopositivc macrophages increased in thalamus. In the brainstem nuclei, an increase in the number of macrophages occurred much earlier in treatment (i.e. day 6). An increase in GFAP-positive astrocytes within thalamus occurred after the changes in mast cells and prior to the increase in macrophages. In brainstem, reactive astrocytes appeared along with the increase in macrophages. These data suggest that mast cell degranulation is a very early response induced by TD, and the resultant release of cytokines and other chemical mediators may play critical roles in both the early vascular damage and eventual tissue destruction within thalamus, but not within brainstem. These results also suggest that macrophages and reactive astrocytes may play more direct roles in the pathogenesis of brainstem lesions.