Catalytic Kinetic Resolution of Cyclic Secondary Amines
Catalytic Kinetic Resolution of Cyclic Secondary Amines
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DOI：
10.1021/ja209472h
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发表时间：
2011-12-14
影响因子：
15
通讯作者：
Bode, Jeffrey W.
中科院分区：
文献类型：
--
作者：
Binanzer, Michael;Hsieh, Sheng-Ying;Bode, Jeffrey W.
通过非手性N-杂环卡宾催化剂和新型手性异羟肟酸助催化剂协同作用的不对称选择性酰胺化反应实现了外消旋环胺的催化拆分。反应在室温下进行，不会产生非挥发性副产物，并通过水萃取提供富含对映体的胺。
The catalytic resolution of racemic cyclic amines has been achieved by an enantioselective amidation reaction featuring an achiral N-heterocyclic carbene catalyst and a new chiral hydroxamic acid cocatalyst working in concert. The reactions proceed at room temperature, do not generate nonvolatile byproducts, and provide enantioen-riched amines by aqueous extraction.