Midface Membranous Bone Lengthening: A One-Year Histological and Morphological Follow-Up of Distraction Osteogenesis
Midface Membranous Bone Lengthening: A One-Year Histological and Morphological Follow-Up of Distraction Osteogenesis
复制标题
中面部膜骨延长：牵引成骨的一年组织学和形态学随访
DOI：
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发表时间：
1998
影响因子：
4.2
通讯作者：
Dina Lewinson
中科院分区：
文献类型：
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作者：
Adi Rachmiel;Dov Laufer;Ian T. Jackson;Dina Lewinson
抽象的。对三只年轻的成年绵羊进行面中部骨延长，在上颌骨截骨后使用牵引成骨术并安装口外固定装置。面中部逐渐牵引，2 mm/天，持续21天，最多约40 mm。注意到面中部明显前移。再保留6周后，取出器械，并对动物随访1年。在牵引期结束时、额外保留6周后以及最后1年后，从牵引区采集活检标本。上颌骨的非牵引区作为对照。标本进行了组织学分析，组织化学，并通过扫描电子显微镜的超微结构模式，矿化，矿物质含量，和近似的Ca 2+浓度。临床和影像学上，所有绵羊完全弥合了实验差距。组织学上，牵张完成时，可见胶原纤维束和细长的骨小梁沿牵张方向排列。在保留期结束时，骨小梁明显增厚，部分被成熟的板层骨取代。在1年结束时，完成重塑过程后，分心区的模式类似于控制区。矿化，反映了定量钙分析，与非牵引区相比，表现出低矿化率延长3周后，增加6周后，1年后变得几乎相同的非牵引区。总之，牵张成骨提供了令人满意的定量和结构性新骨。
Abstract. Midface bone lengthening was performed on three young, adult sheep using distraction osteogenesis following osteotomy of the maxilla and mounting of an extraoral fixation device. The midface was gradually distracted, 2 mm/day, for 21 days, up to approximately 40 mm. A marked midface advancement was noted. Following a further 6 weeks of retention, the device was removed and the animals were followed for 1 year. Biopsies specimens were taken from the distracted area at the end of the distraction period, after the additional 6 weeks of retention, and finally 1 year later. A nondistracted area of the maxillary bone served as control. The specimens were analyzed histologically, histochemically, and by scanning electron microscopy for the ultrastructural pattern, mineralization, mineral content, and approximate Ca2+ concentration. Clinically and radiographically, all sheep fully bridged the experimental gap. Histologically, at the completion of distraction, collagen bundles and slender bone trabeculae oriented in the direction of the distraction could be seen. At the end of the retention period, the trabeculae thickened noticeably and were partially replaced by mature lamellar bone. At the end of 1 year and after completion of the process of remodeling, the pattern of the distracted area resembled the control area. The mineralization, as reflected by quantitative calcium analysis, compared with the nondistracted area, demonstrated a low rate of mineralization after 3 weeks of lengthening, increased 6 weeks later, and after 1 year became nearly the same as in the nondistracted area. In conclusion, distraction osteogenesis provides satisfactory quantitative and structural new bone.