Cervical spinal cord injury alters the pattern of breathing in anesthetized rats
Cervical spinal cord injury alters the pattern of breathing in anesthetized rats
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DOI：
10.1152/jappl.2001.91.6.2451
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发表时间：
2001-12-01
影响因子：
3.3
通讯作者：
Bolser, DC
中科院分区：
文献类型：
--
作者：
Golder, FJ;Reier, PJ;Bolser, DC
慢性颈髓损伤改变呼吸功能和可塑性的机制尚不清楚。我们推测C-2脊髓半切会改变迷走神经机制控制的呼吸模式。在麻醉对照组和C2半切组大鼠伤后1和2 mo测定呼气量（VE）和呼吸频率（RR）。C-2半切改变了两个伤后时间间隔的呼吸模式。损伤大鼠利用较高的RR和较低的VE来维持与对照大鼠相同的每分钟通气量。双侧迷走神经切断后，损伤大鼠的呼吸模式与对照组无差异。迷走神经切断术前，损伤大鼠在伤后2个月时呼吸增强的频率较高;然而，两组之间呼吸增强的VE没有差异。总之，C-2半切通过迷走神经机制改变了损伤后1和2个月的呼吸模式。
The mechanisms by which chronic cervical spinal cord injury alters respiratory function and plasticity are not well understood. We speculated that spinal hemisection at C-2 would alter the respiratory pattern controlled by vagal mechanisms. Expired volume (VE) and respiratory rate (RR) were measured in anesthetized control and C-2-hemisected rats at 1 and 2 mo postinjury. C-2 hemisection altered the pattern of breathing at both postinjury time intervals. Injured rats utilized a higher RR and lower VE to maintain the same minute ventilation as control rats. After bilateral vagotomy, the pattern of breathing in injured rats was not different from controls. The frequency of augmented breaths was higher in injured rats at 2 mo postinjury before vagotomy; however, the VE of augmented breaths was not different between groups, In conclusion, C-2 hemisection alters the pattern of breathing at 1 and 2 mo postinjury via vagal mechanisms.