SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models.
SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models.
复制标题
SIRT1 调节糖尿病和非糖尿病模型的认知表现以及学习和记忆能力
DOI：
10.1155/2017/7121827
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发表时间：
2017
影响因子：
4.3
通讯作者：
Wang G
中科院分区：
文献类型：
--
作者：
Cao Y;Yan Z;Zhou T;Wang G
Type 2 diabetes mellitus is a complex age-related metabolic disease. Cognitive dysfunction and learning and memory deficits are main characteristics of age-related metabolic diseases in the central nervous system. The underlying mechanisms contributing to cognitive decline are complex, especially cognitive dysfunction associated with type 2 diabetes mellitus. SIRT1, as one of the modulators in insulin resistance, is indispensable for learning and memory. In the present study, deacetylation, oxidative stress, mitochondrial dysfunction, inflammation, microRNA, and tau phosphorylation are considered in the context of mechanism and significance of SIRT1 in learning and memory in diabetic and nondiabetic murine models. In addition, future research directions in this field are discussed, including therapeutic potential of its activator, resveratrol, and application of other compounds in cognitive improvement. Our findings suggest that SIRT1 might be a potential therapeutic target for the treatment of cognitive impairment induced by type 2 diabetes mellitus.
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SIRT1 调节海马神经元树突状发育。
影响因子：
3.7
作者：
Codocedo JF;Allard C;Godoy JA;Varela-Nallar L;Inestrosa NC
通讯作者：
Inestrosa NC
影响因子：
4.8
作者：
Cheng XR;Cui XL;Zheng Y;Zhang GR;Li P;Huang H;Zhao YY;Bo XC;Wang SQ;Zhou WX;Zhang YX
通讯作者：
Zhang YX
影响因子：
29
作者：
Chalkiadaki A;Guarente L
通讯作者：
Guarente L
DOI：
10.3233/jad-160505
发表时间：
2017
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Fried PJ;Schilberg L;Brem AK;Saxena S;Wong B;Cypess AM;Horton ES;Pascual-Leone A
通讯作者：
Pascual-Leone A
影响因子：
4
作者：
Du, Lai-Ling;Chai, Da-Min;Zhou, Xin-Wen
通讯作者：
Zhou, Xin-Wen