Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life.
Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life.
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DOI：
10.1016/j.cell.2016.04.055
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发表时间：
2016-05-05
期刊：
影响因子：
64.5
通讯作者：
Barton GM
中科院分区：
文献类型：
--
作者：
Koch MA;Reiner GL;Lugo KA;Kreuk LS;Stanbery AG;Ansaldo E;Seher TD;Ludington WB;Barton GM
为了维持宿主和肠道微生物群之间的共生关系，必须建立适当的粘膜T细胞对共生抗原的反应。小鼠通过母体获得了免疫球蛋白和免疫球蛋白A；前者主要参与了对病原体的被动免疫，而后者则参与了宿主-共生共生。在这里，我们报告了一个令人惊讶的观察结果，即小鼠产生不依赖T细胞且主要依赖Toll样受体(TLR)的针对其肠道微生物区系的IgG2b和IgG3抗体反应。我们证明，母体获得这些抗体会抑制出生后粘膜T滤泡辅助反应和随后的生发中心B细胞反应。这项工作揭示了一个反馈回路，在这个回路中，依赖于T细胞的TLR抗体限制了对新获得的共生抗原的粘膜适应性免疫反应，并揭示了母体免疫球蛋白的更广泛的功能。
To maintain a symbiotic relationship between the host and its resident intestinal microbiota, appropriate mucosal T cell responses to commensal antigens must be established. Mice acquire both IgG and IgA maternally; the former has primarily been implicated in passive immunity to pathogens while the latter mediates host-commensal mutualism. Here we report the surprising observation that mice generate T cell independent and largely Toll-like receptor (TLR) dependent IgG2b and IgG3 antibody responses against their gut microbiota. We demonstrate that maternal acquisition of these antibodies dampens mucosal T follicular helper responses and subsequent germinal center B cell responses following birth. This work reveals a feedback loop whereby T cell independent, TLR-dependent antibodies limit mucosal adaptive immune responses to newly acquired commensal antigens and uncovers a broader function for maternal IgG.