Amyloid β protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease
Amyloid β protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease
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DOI：
10.1016/s0304-3940(01)01754-2
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发表时间：
2001-05-18
影响因子：
2.5
通讯作者：
Mehta, SP
中科院分区：
文献类型：
--
作者：
Mehta, PD;Pirttila, T;Mehta, SP
我们对 50 名疑似阿尔茨海默病患者的匹配脑脊液 (CSF) 和血浆中的淀粉样β蛋白 1-40 (Aβ40) 和 1-42 (Aβ42) 以及 α1-抗胰凝乳蛋白酶 (ACT) 进行了定量，并分析了其与年龄、性别、简易精神状态检查 (MMSE) 和载脂蛋白 E 表型的关系。 CSF Aβ40和Aβ42水平与血浆水平没有相关性。脑脊液和血浆 A β 40 和 A β 42 水平与年龄、性别和 MMSE 评分无关。 CSF ACT 和血浆 ACT 水平之间存在显着相关性。数据表明血浆 ACT 可以穿过血脑屏障。然而，CSF A β 40 和 A β 42 水平与血浆中的水平缺乏相关性，这表明 CSF 和血浆中的 A β 来源不同。 (C) 2001 Elsevier Science Ireland Ltd. 保留所有权利。
We quantitated amyloid beta proteins 1-40 (A beta 40) and 1-42 (A beta 42), and alpha1-antichymotrypsin (ACT) in matched cerebrospinal fluid (CSF) and plasma of 50 patients with probable Alzheimer disease, and analyzed the relationships with age, sex, Mini-Mental State Examination (MMSE), and apolipoprotein E phenotype. There was no relation between CSF A beta 40 and A beta 42 levels with those of plasma. CSF and plasma A beta 40 and A beta 42 levels showed no association with age, sex, and MMSE score. There was a significant correlation between CSF ACT and plasma ACT levels. The data suggest that plasma ACT crosses the blood-brain barrier. However, a lack of correlation between CSF A beta 40 and A beta 42 levels with those of plasma suggests that A beta in CSF and plasma originates from different sources. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.