Serum levels of interleukin-6 and C-reactive protein correlate with body mass index across the broad range of obesity
Serum levels of interleukin-6 and C-reactive protein correlate with body mass index across the broad range of obesity
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DOI：
10.1177/0148607104028006410
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发表时间：
2004-11-01
影响因子：
3.4
通讯作者：
Bistrian, BR
中科院分区：
文献类型：
--
作者：
Khaodhiar, L;Ling, PR;Bistrian, BR
背景 人们已经注意到，肥胖患者血清中典型地发现炎症标志物升高，例如肿瘤坏死因子-α (TNF)、可溶性 TNF 受体 II (sTNF-RII)、白细胞介素 6 (IL-6) 和 C 反应蛋白 (CRP)。在这项研究中，我们检查了这些标志物与非肥胖、肥胖和病态肥胖个体的 BMI 的相关性，以探索广泛的肥胖范围内的这种关系。方法：本研究共纳入 9 名非肥胖成人，包括正常体重和超重（体重指数 [BMI] < 30 kg/m(2)）和 41 名肥胖（BMI 大于或等于 30 kg/m(2)）成人。在肥胖受试者中，11 名受试者为 I 级或 II 级肥胖（BMI 大于或等于 30 且 < 40 kg/m(2)），30 名受试者为病态肥胖（III 级肥胖，BMI 大于或等于 40 k g/m(2)）。测量葡萄糖、胰岛素、TNF、sTNF-RII、IL-6 和 CRP 的血清水平。结果：与非肥胖受试者相比，肥胖受试者（BMI大于或等于30 k g/m(2)）的TNF、sTNF-RII、IL-6和CRP血清水平显着升高。肥胖受试者的 sTNF-RII、IL-6 和 CRP（而非 TNF）的血清水平与 BMI 呈正相关。然而，在病态肥胖受试者中，只有 IL-6 和 CRP 的血清浓度与 BMI 保持相关，这主要是因为男性存在这种关系。结论：目前的结果支持肥胖代表炎症状态的证据。在病态肥胖中，只有 IL-6 和 CRP 与 BMI 相关，特别是在男性中，表明 IL-6 可能以内分泌方式分泌，与脂肪量的扩张成比例，特别是在腹部区域，同时肝脏产生的 CRP 相应增加。
Background It has been noted that elevated inflammatory markers, such as tumor necrosis factor-alpha (TNF), soluble TNF receptor II (sTNF-RII), interleukin 6 (IL-6) and C-reactive protein (CRP), are characteristically found in the serum in obese patients. In this study, we examined the correlation of these markers with BMI in nonobese, obese, and morbidly obese individuals to explore this relationship across the broad range of obesity. Methods: A total of 9 nonobese, including normal and over-weight (body mass index [BMI] < 30 kg/m(2)) and 41 obese (BMI greater than or equal to 30 kg/m(2)) adults were included in this study. Among obese subjects, 11 subjects were grade I or II obese (BMI greater than or equal to 30 and < 40 kg/m(2)), and 30 subjects were morbidly obese (grade III obese, BMI greater than or equal to 40 k g/m(2)). Serum levels of glucose, insulin, TNF, sTNF-RII, IL-6, and CRP were measured. Results: Obese subjects (BMI greater than or equal to 30 k g/m(2)) had significantly higher serum levels of TNF, sTNF-RII, IL-6, and CRP compared with nonobese subjects. Serum levels of sTNF-RII, IL-6, and CRP, but not TNF, were positively correlated with BMI in obese subjects. However, in morbidly obese subjects, only the serum concentrations of IL-6 and CRP remained correlated with BMI, primarily because of this relationship in men. Conclusions: The present results support evidence that obesity represents an inflammatory state. In morbid obesity, the correlation of only IL-6 and CRP with BMI, particularly in males, suggests that IL-6 may be secreted in an endocrine manner in proportion to the expansion of fat mass particularly in the abdominal region, with a corresponding increase in hepatic production of CRP.