Incidence and burden of rotavirus gastroenteritis in Japan, as estimated from a prospective sentinel hospital study
Incidence and burden of rotavirus gastroenteritis in Japan, as estimated from a prospective sentinel hospital study
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DOI：
10.1086/431503
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发表时间：
2005-09-01
影响因子：
6.4
通讯作者：
Kilgore, PE
中科院分区：
文献类型：
--
作者：
Nakagomi, T;Nakagomi, O;Kilgore, PE
我们评估了日本秋田县3家哨点医院轮状病毒感染相关疾病的住院和相关费用负担。2001年1月至2002年12月，共有443名5岁以下儿童因急性胃肠炎住院。在收集的422份粪便标本中，244份（58%）轮状病毒检测呈阳性。只有7.8%的轮状病毒病相关住院病例涉及6个月以下的婴儿，而大多数病例（39%）是在出生后第二年报告的，89%的病例发生在36个月内。根据改良的20分严重程度评分系统，导致住院的轮状病毒胃肠炎的平均严重程度评分为16.5分。平均相关直接医疗费用为136，000日元（1236美元），3家医院之间相似。< 5岁儿童轮状病毒病相关住院的估计发生率为7.9 - 17.6次住院/1000人-年，5岁时的估计累积发生率为6.6%。因此，大约每15名儿童中就有1名在出生后第5年因轮状病毒腹泻而需要住院治疗。在日本，这意味着每年将有78，000名5岁以下儿童住院，直接医疗费用达100亿日元（9，600万美元）。在日本，轮状病毒胃肠炎造成的负担是巨大的，通过引进疫苗可能会减少。
We assessed the burden of rotavirus infection-related disease, in terms of hospitalization and associated costs, at 3 sentinel hospitals in Akita prefecture, Japan. From January 2001 through December 2002, a total of 443 children < 5 years of age were hospitalized for acute gastroenteritis. Of 422 stool specimens collected, 244 (58%) tested positive for rotavirus. Only 7.8% of the rotavirus disease-associated hospitalizations involved infants < 6 months of age, whereas most cases of disease (39%) were reported in the second year of life, and 89% of cases had occurred by 36 months of age. The mean severity score for rotavirus gastroenteritis resulting in hospitalization was 16.5, according to the modified 20-point severity scoring system. The average associated direct medical cost was 136,000 yen (US $1236) per case and was similar among the 3 hospitals. The estimated incidence of rotavirus disease-associated hospitalizations among children < 5 years of age was 7.9 - 17.6 hospitalizations/1000 person-years, and the estimated cumulative incidence by 5 years of age was 6.6%. Thus, similar to 1 in 15 children will require hospitalization due to rotavirus diarrhea by their fifth year of life. In Japan, this would mean that 78,000 children < 5 years of age would be hospitalized each year, resulting in a direct medical cost of 10 billion yen (US $96 million). The burden associated with rotavirus gastroenteritis in Japan is substantial and might be reduced through the introduction of vaccines.