On-chip single nanoparticle detection and sizing by mode splitting in an ultrahigh-Q microresonator
On-chip single nanoparticle detection and sizing by mode splitting in an ultrahigh-Q microresonator
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DOI：
10.1038/nphoton.2009.237
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发表时间：
2010-01-10
期刊：
影响因子：
35
通讯作者：
Yang, Lan
中科院分区：
文献类型：
--
作者：
Zhu, Jiangang;Ozdemir, Sahin Kaya;Yang, Lan
以高分辨率检测和测量单个纳米颗粒的能力对于理解单个颗粒的行为和有效利用其强大的尺寸依赖性来开发创新产品至关重要。我们报告的实时，原位检测和尺寸的单个纳米粒子，半径下降到30纳米，使用模式分裂在单片超高品质因数（Q）回音壁模式微谐振器。粒子结合将回音壁模式分裂成两个光谱移动的共振模式，形成自参考检测方案。该技术提供了上级噪声抑制，并且能够在微尺度装置中利用单次测量来提取精确的颗粒尺寸信息。我们的方法既不需要标记的颗粒，也不需要先验信息，他们在介质中的存在，提供了一个有效的平台，研究纳米粒子在单粒子分辨率。
The ability to detect and size individual nanoparticles with high resolution is crucial to understanding the behaviour of single particles and effectively using their strong size-dependent properties to develop innovative products. We report real-time, in situ detection and sizing of single nanoparticles, down to 30 nm in radius, using mode splitting in a monolithic ultrahigh-quality-factor (Q) whispering-gallery-mode micro-resonator. Particle binding splits a whispering-gallery mode into two spectrally shifted resonance modes, forming a self-referenced detection scheme. This technique provides superior noise suppression and enables the extraction of accurate particle size information with a single-shot measurement in a microscale device. Our method requires neither labelling of the particles nor a priori information on their presence in the medium, providing an effective platform to study nanoparticles at single-particle resolution.