Biochemical effect of a ketogenic diet on the brains of obese adult rats
Biochemical effect of a ketogenic diet on the brains of obese adult rats
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DOI：
10.1016/j.jocn.2009.11.005
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发表时间：
2010-07-01
影响因子：
2
通讯作者：
Abd El-Latif, Sally K.
中科院分区：
文献类型：
--
作者：
Mohamed, Hoda E.;El-Swefy, Sahar E.;Abd El-Latif, Sally K.
超重，特别是腹部肥胖，可引起或加重心血管和代谢疾病。肥胖也是阿尔茨海默病（AD）的已证实的危险因素。各种研究已经证明生酮饮食（KD）在减轻体重和改变神经退行性疾病的疾病活动方面的有益作用。包括AD因此，在本研究中，我们检测了与肥胖相关的代谢和神经退行性变化，以及与对照饮食喂养的肥胖大鼠相比，KD在肥胖成年大鼠中可能的神经保护作用。喂食KD的肥胖大鼠表现出显著的体重减轻、脂质分布和胰岛素抵抗的改善以及脂肪组织中脂联素mRNA表达的上调。此外，KD引发脑淀粉样蛋白前体、载脂蛋白E和半胱天冬酶-3 mRNA表达的显著下调以及脑氧化应激反应的改善。这些研究结果表明，KD具有抗肥胖和神经保护作用（C）2009 Elsevier Ltd版权所有
Excess weight, particularly abdominal obesity, can cause or exacerbate cardiovascular and metabolic disease Obesity is also a proven risk factor for Alzheimer's disease (AD) Various studies have demonstrated the beneficial effects of a ketogenic diet (KD) in weight reduction and in modifying the disease activity of neurodegenerative disorders. including AD Therefore, in this study we examined the metabolic and neurodegenerative changes associated with obesity and the possible neuroprotective effects of a KD in obese adult rats Compared with obese rats fed a control diet. obese rats fed a KD showed significant weight loss, improvement in lipid profiles and insulin resistance, and upregulation of adiponectin mRNA expression in adipose tissue In addition, the KD triggered significant downregulation of brain amyloid protein precursor, apolipoprotein E and caspase-3 mRNA expression, and improvement of brain oxidative stress responses. These findings suggest that a KD has anti-obesity and neuroprotective effects (C) 2009 Elsevier Ltd All rights reserved