Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer
Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer
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DOI：
10.4161/cbt.7.1.5131
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发表时间：
2008-01-01
影响因子：
3.6
通讯作者：
Young, Charles Y. F.
中科院分区：
文献类型：
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作者：
Gazi, Mozammel H.;He, MeiLan;Young, Charles Y. F.
通过蛋白质表达谱、质谱和/或RT-PCR分析，我们首次发现IgG Fc结合蛋白（Fc γ BP）在人和小鼠前列腺中表达，与Fc γ受体不同。在转基因腺癌小鼠前列腺（TRAMP）小鼠中，Fc γ BP下调与前列腺癌进展之间存在强相关性。Fc γ BP基因表达在人前列腺肿瘤组织和前列腺细胞系中显著降低或丧失。差异表达的Fc γ BP可以反映其在前列腺恶性肿瘤中的潜在作用以及癌症进展的指标。
By means of protein expression profile, mass spectral and/or RT-PCR analyses we found for the first time IgG Fc binding protein (Fc gamma BP), distinct from Fc gamma receptors is expressed in both human and mouse prostates. There is a strong correlation between downregulation of Fc gamma BP and the progression of prostate cancer in Transgenic Adenocarcinoma Mouse Prostate (TRAMP) mice. Fc gamma BP gene expression is significantly reduced or lost in human prostate tumor tissues and prostate cell lines. The differentially expressed Fc gamma BP could reflect its potential role in prostate malignancy as well as an indicator for progression of the cancer.