Protein Photoconductors and Photodiodes
Protein Photoconductors and Photodiodes
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DOI：
10.1002/anie.201103341
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发表时间：
2011-01-01
影响因子：
16.6
通讯作者：
Watanabe, Yoshihito
中科院分区：
文献类型：
--
作者：
Tokita, Yuichi;Yamada, Seiji;Watanabe, Yoshihito
通过蛋白质的远程电子转移（ET）在生命系统中起着重要作用。ET蛋白可以被视为具有“掺杂剂”（氧化还原或光活性物质）的宽带隙分子半导体，提供电子或空穴定位位点，尽管蛋白质支架具有绝缘特性。[1-10]为了阐明控制这些非绝热反应速率的因素，许多研究小组对蛋白质中的分子内ET进行了详细的研究。[1 - 9,11 - 13] Dutton及其同事提出了一个方形势垒ET速率模型[11,12]，而Gray及其同事则表明ET取决于电子供体和受体之间的介质结构。[5-9]我们研究了锌取代细胞色素b562 （Zn-cytb562）和锌取代细胞色素c （Zn-cytc）两种蛋白的光诱导ET，它们的半导体特性取决于其分子表面的电荷分布：Zn-cytb562具有n型半导体特性，而Zn-cytc为p型半导体，尽管这两种体系的活性中心几乎相同。这一发现可能会打开基于蛋白质的电子学的世界，因为蛋白质的半导体特性可以通过表面电荷的变化来控制。
Long-range electron transfer (ET) through proteins plays important roles in living systems. ET proteins can be regarded as wide-band-gap molecular semiconductors with “dopants”(redox or photoactive species) that provide an electron-or hole-localizing site, though the protein scaffold has insulating character.[1–10] Intramolecular ET in proteins has been investigated in detail by many groups to elucidate the factors that control the rates of these nonadiabatic reactions.[1–9, 11–13] Dutton and co-workers proposed a square barrier ET rate model,[11, 12] while Gray and colleagues showed that ET depends on the structure of the medium between an electron donor and acceptor.[5–9]We have investigated photoinduced ET in two proteins, zinc-substituted cytochrome b562 (Zn-cytb562) and zinc-substituted cytochrome c (Zn-cytc), the semiconductor properties of which depend on the charge distribution on their molecular surfaces: Zn-cytb562 has n-type semiconductor character while Zn-cytc is p-type, although the active center of the two systems is virtually identical. This finding may open up the world of protein-based electronics, because the semiconductor character of proteins could be controlled by variations in surface charge.