The assessment of health-related quality of life and related factors in Chinese elderly patients undergoing chemotherapy for advanced cancer: A cross-sectional study
The assessment of health-related quality of life and related factors in Chinese elderly patients undergoing chemotherapy for advanced cancer: A cross-sectional study
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DOI：
10.1016/j.ejon.2014.03.005
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发表时间：
2014-08-01
影响因子：
2.8
通讯作者：
Xu, Yongyong
中科院分区：
文献类型：
--
作者：
Li, Qiuping;Lin, Yi;Xu, Yongyong
研究目的：(0)评估中国老年癌症患者健康相关生活质量（HRQOL）并分析影响HRQOL的潜在因素；（ii）评估医疗结果36项简短健康调查（SF-36）与欧洲癌症研究和治疗组织生活质量问卷（EORTC QLQ-C30）之间可能存在的相关性。方法与样本：对109例老年晚期癌症化疗患者进行HRQOL、焦虑、抑郁的问卷调查。HRQOL采用SF-36和EORTC QLQ-C30测定。焦虑和抑郁采用医院焦虑抑郁量表（HADS）进行测量。主要结果：SF-36角色身体（25.92 +/- 37.10）、角色情绪（36.12 +/- 43.50）和EORTC QLQ-C30角色功能（46.94 +/- 36.86）分别为SF-36和EORTC QLQ-C30的最差域。财务影响（55.77 +/- 36.55）和疲劳（46.18 +/- 26.48）是EORTC QLQ C-30所有9个症状相关量表中得分最高的前两个。SF-36与EORTC QLQ-C30的相关矩阵显示，总体而言，同一健康域各量表之间存在较好的相关性，不同健康域各量表之间存在较低的相关性。结论：这项研究的发现强调了角色功能、经济影响、疲劳、焦虑和抑郁是老年癌症患者最能从干预中受益的领域。这些发现也引起了人们对老年癌症患者HRQOL及其相关因素的关注。我们强烈推荐为改善癌症患者的HRQOL而开发的干预措施。(C) 2014 Elsevier Ltd.版权所有。
Purpose of the research: (0 To assess the health-related quality of life (HRQOL) and analyse the potential contributing factors of HRQOL in elderly cancer patients in China; and (ii) to evaluate the possible correlation between the Medical Outcomes 36-Item Short Form Health Survey (SF-36) and the European Organization for Research and Treatment of Cancer, quality of life questionnaire (EORTC QLQ-C30).Methods and sample: A total of 109 elderly patients undergoing chemotherapy with advanced cancer completed a survey assessing HRQOL, anxiety and depression. HRQOL was measured by SF-36 and EORTC QLQ-C30. Anxiety and depression, was measured by the Hospital Anxiety and Depression Scale (HADS).Key results: Scales pertaining to role functioning, including SF-36 role physical (25.92 +/- 37.10) and role emotional (36.12 +/- 43.50), EORTC QLQ-C30 role functioning (46.94 +/- 36.86), were the worst domains of SF-36 and EORTC QLQ-C30 respectively. Financial impact (55.77 +/- 36.55) and fatigue (46.18 +/- 26.48) were the top two highest scores among all nine symptom-related scales of EORTC QLQ C-30. The correlation matrix of SF-36 versus EORTC QLQ-C30 showed that, in general, there was good correlation between scales pertaining to the same health domain, and low correlation was observed between scales pertaining to different domains.Conclusions: The findings of this study highlight role functioning, financial impact, fatigue, anxiety, and depression as areas where elderly cancer patients could most benefit from intervention. These findings also call attention to HRQOL and its related factors in elderly cancer patients. Interventions to be developed for improving HRQOL in cancer patients are highly recommended. (C) 2014 Elsevier Ltd. All rights reserved.