Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology.
Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology.
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DOI：
10.1017/s0140525x15001727
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Arnsten AF
中科院分区：
文献类型：
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作者：
Abdallah CG;Averill LA;Krystal JH;Southwick SM;Arnsten AF
Mather及其同事提出了一个令人印象深刻的唤醒诱导去甲肾上腺素（NE）释放及其在选择性增强/抑制感知，注意力和记忆巩固中的作用的跨学科模型。该模型将需要实证研究来测试其有效性和超越经典NE回路的可推广性，因为它简化了极其复杂和异构的动作，包括与高级认知回路和精神病理学相关的NE机制。
Mather and colleagues present an impressive interdisciplinary model of arousal-induced norepinephrine (NE) release and its role in selectively enhancing/inhibiting perception, attention, and memory consolidation. This model will require empirical investigation to test its validity and generalizability beyond classic NE circuits as it simplifies extremely complex and heterogeneous actions including NE mechanisms related to higher cognitive circuits and psychopathology.