Association Between Self-Reported Dental Health Status and Onset of Dementia: A 4-Year Prospective Cohort Study of Older Japanese Adults from the Aichi Gerontological Evaluation Study (AGES) Project
Association Between Self-Reported Dental Health Status and Onset of Dementia: A 4-Year Prospective Cohort Study of Older Japanese Adults from the Aichi Gerontological Evaluation Study (AGES) Project
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DOI：
10.1097/psy.0b013e318246dffb
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发表时间：
2012-04-01
影响因子：
3.3
通讯作者：
Hirata, Yukio
中科院分区：
文献类型：
--
作者：
Yamamoto, Tatsuo;Kondo, Katsunori;Hirata, Yukio
目的：研究表明，有认知障碍的人牙齿健康状况不佳。然而，因果关系的方向仍然未知。这项前瞻性队列研究旨在确定日本老年人自我报告的四个牙齿健康变量与痴呆发病之间的关系。方法：对4425名65岁及以上的居民进行分析。四个自我报告的牙齿健康变量包括牙齿数量和/或假牙的使用，咀嚼能力，是否定期看牙医，以及牙齿健康的护理。数据是通过2003年的自我调查问卷收集的。2003年至2007年期间的痴呆症发病记录是从负责公共长期护理保险系统的各市获得的。年龄、收入、体重指数、目前疾病、饮酒、运动和健忘被用作协变量。结果：220名参与者发生痴呆。单因素Cox比例风险模型显示，牙齿健康变量与痴呆之间存在显著相关性。在对所有协变量进行完全调整的模型中，受访者发生痴呆的风险比（95%置信区间）如下：牙齿少和不戴假牙者的风险比（95%置信区间）为1.85 (1.04-3.31)；咀嚼不良者为1.25分（0.81-1.93分）；没有定期看牙医的则为1.44 (1.04-2.01)；没有注意牙齿健康的人的得分为1.76（0.96-3.20）。结论：即使在调整了可用的协变量后，日本老年队列中，没有假牙的牙齿较少和没有定期牙医，而不是咀嚼不良和对牙齿健康的不良态度，与较高的痴呆发病风险相关。
Objectives: Studies have shown that people with cognitive impairment have poor dental health. However, the direction of causality remains unknown. This prospective cohort study aimed to determine the association between four self-reported dental health variables and dementia onset in older Japanese people. Methods: Analysis was conducted on 4425 residents 65 years or older. Four self-reported dental health variables included the number of teeth and/or use of dentures, ability to chew, presence/absence of a regular dentist, and taking care of dental health. Data were collected using self-administered questionnaires given in 2003. Records of dementia onset during 2003 to 2007 were obtained from municipalities in charge of the public long-term care insurance system. Age, income, body mass index, present illness, alcohol consumption, exercise, and forgetfulness were used as covariates. Results: Dementia onset was recorded in 220 participants. Univariate Cox proportional hazards models showed significant associations between the dental health variables and dementia ilia In models fully adjusted for all covariates, hazard ratios (95% confidence intervals) of dementia onset of respondents were as follows: 1.85 (1.04-3.31) for those with few teeth and without dentures; 1.25 (0.81-1.93) for those who could not chew very well; 1.44 (1.04-2.01) for those who did not have a regular dentist; and 1.76 (0.96-3.20) for those who did not take care of their dental health. Conclusions: Few teeth without dentures and absence of a regular dentist, not poor mastication and poor attitudes toward dental health, were associated with higher risk of dementia onset in the older Japanese cohort even after adjustment for available covariates.