Regional cerebral hemodynamics during re-build up phenomenon in childhood moyamoya disease - An analysis using Tc-99m-HMPAO SPECT
Regional cerebral hemodynamics during re-build up phenomenon in childhood moyamoya disease - An analysis using Tc-99m-HMPAO SPECT
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DOI：
10.1007/bf00266821
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发表时间：
1996-03-01
影响因子：
1.4
通讯作者：
Mitumori, K
中科院分区：
文献类型：
--
作者：
Kazumata, K;Kuroda, S;Mitumori, K
我们使用Tc-99 m-HMPAO单光子发射计算机断层扫描（Tc-99 m-HMPAO SPECT）和Tc-99 m-HMPAO SPECT研究了缺血缺氧在儿童烟雾病脑电图上出现再建立现象中的作用。在报告的病例中，在双侧顶枕区的重建现象期间观察到局部脑血流量（rCBF）严重减少，其中乙酰唑胺试验显示灌注储备严重受损。在脑电图上，重建现象起源于这些区域。此外，30 s后，即使在没有观察到严重缺血的地方，整个半球也出现了重建现象。这些结果表明，过度通气引起的rCBF减少在重建现象的出现中起着关键作用，但过度通气后的缺血性缺氧等其他因素在这种现象的发展中也很重要。
We investigated the role of ischemic hypoxia in the appearance of re-build-up phenomenon on electroencephalography in childhood moyamoya disease using Tc-99m-hexamethyl propyleneamine oxime and single photon emission computed tomography (Tc-99m-HMPAO SPECT). In the case reported on, critical reduction of regional cerebral blood flow (rCBF) was observed during rebuild-up phenomenon in the bilateral parieto-occipital area where acetazolamide testing revealed severe impairment of the perfusion reserve. On electroencephalography, the rebuild-up phenomenon originated in these areas. In addition, re-build-up phenomenon developed into the entire hemisphere 30 s later, even where the severe ischemia was not observed. These results suggest that rCBF reduction induced by hyperventilation plays a critical role in the appearance of the re-build-up phenomenon, but other factors such as ischemic hypoxia after hyperventilation are also important in the development of this phenomenon.