Permeation of 4-cyanophenol and methyl paraben from powder and saturated aqueous solution through silicone rubber membranes and human skin
Permeation of 4-cyanophenol and methyl paraben from powder and saturated aqueous solution through silicone rubber membranes and human skin
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DOI：
10.1002/jps.20735
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发表时间：
2006-11-01
影响因子：
3.8
通讯作者：
Bunge, Annette L.
中科院分区：
文献类型：
--
作者：
Romonchuk, Wayne J.;Bunge, Annette L.
目的是比较两种模型化合物的纯粉末和饱和水溶液向均质硅橡胶（聚二甲基硅氧烷）膜（SRM）和非均质人体皮肤的渗透，并测试固体化学品不吸收（除非存在液体）的常见假设。通过SRM的来自粉末的4-氰基苯酚（CP）的稳态通量（0.0684 +/- 0.0040 mg/cm（2.）h）几乎与饱和溶液相同（0.0789 +/-0.0064 mg/cm（2.）h），表明固体化学品可以在没有液体存在的情况下吸收。CP通过单个受试者皮肤的稳态通量比粉末小得多（0.0118 +/- 0.0064 mg/cm（2.）h）比从饱和溶液（0.168 +/-0.033mg/cm（2.）h）。粉末相对于饱和水溶液的平均通量在皮肤中为7.24%，而在SRM中CP为87.2%，在皮肤中为9.02%，而在SRM中对羟基苯甲酸甲酯为99.9%。很明显，粉末状化学品可能会被SRM和皮肤吸收，而表面油或水分是不必要的。然而，SRM被证明是CP和MP粉末经皮渗透的不良替代物。(c)2006 Wiley-Liss，Inc.和美国药剂师协会
The objectives were to compare permeation from neat powder and saturated aqueous solution of two model compounds into homogeneous silicone rubber (polydimethylsiloxane) membranes (SRM) and human skin, which is heterogeneous, and to test the common assumption that solid chemicals do not absorb unless liquid is present. The steady-state flux of 4-cyanophenol (CP) through SRM from the powder (0.0684 +/- 0.0040 mg/cm(2.)h) was almost the same as from a saturated solution (0.0789 +/- 0.0064 mg/cm(2.)h), indicating that solid chemicals can absorb without the presence of liquids. The steady-state flux of CP through skin of a single subject was much smaller from the powder (0.0118 +/- 0.0064 mg/cm(2.)h) than from the saturated solution (0.168 +/- 0.033 mg/cm(2.)h). The average flux for powder relative to the saturated aqueous solution was 7.24% in skin compared with 87.2% in SRM for CP and 9.02% in skin compared with 99.9% in SRM for methyl paraben. It is evident that absorption into SRM and skin can occur from powdered chemicals and that surface oils or moisture are unnecessary. However, SRM proved to be a poor surrogate for dermal permeation from powders of CP and MP. (c) 2006 Wiley-Liss, Inc. and the American Pharmacists Association.