Targeted hyperthermia using metal nanoparticles.

Targeted hyperthermia using metal nanoparticles.
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DOI:
10.1016/j.addr.2009.11.006
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发表时间:
2010-03-08
影响因子:
16.1
通讯作者:
Curleya, Steven A.
Curleya, Steven A.
中科院分区:
医学1区
文献类型:
--
作者:
Cherukuri, Paul;Glazer, Evan S.;Curleya, Steven A.

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Despite the use of hyperthermia to treat cancer for thousands of years, the challenge of only heating malignant cells remains daunting. In pre-clinical and early clinical trials, metal nanoparticles induce hyperthermic cytotoxicity when exposed to near-infrared radiation or radiofrequency fields. We discuss the emerging roles of nanoparticles, especially gold, in the hyperthermic treatment of cancer. In addition, we discuss the similarities of radiofrequency ablation and nanoparticle mediated cytotoxicity.
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