Conduction deficits of callosal fibres in early multiple sclerosis
Conduction deficits of callosal fibres in early multiple sclerosis
复制标题
DOI：
10.1136/jnnp.68.5.633
复制
发表时间：
2000-05-01
影响因子：
11
通讯作者：
Meyer, BU
中科院分区：
文献类型：
--
作者：
Schmierer, K;Niehaus, L;Meyer, BU
目的：探讨经颅磁刺激(TMS)诱发的经穹隆抑制(TI)对早期多发性硬化症中枢传导功能障碍的诊断价值。TMS诱发的皮质脊髓介导的兴奋性反应被认为是多发性硬化症的敏感诊断工具。最近，TMS诱发的TI被引入作为一种新的范式来测试两侧手部相关运动皮质相互连接的痂纤维的功能。方法对50例早期复发-缓解型多发性硬化症患者进行运动皮质的局灶性TMS检查。结果：TMS显示62%的患者皮质脊髓介导的反应异常，80%的患者存在TI异常。结论-TI的评估可以发现脑室周围白质内以前神经生理学技术无法检测到的病变。这一新的范例增加了TMS检测早期多发性硬化症中枢传导缺陷的敏感性。
Objective-To study the diagnostic usefulness of transcallosal inhibition (TI) elicited by transcranial magnetic stimulation (TMS) in detecting central conduction deficits in early multiple sclerosis. Corticospinally mediated excitatory responses evoked by TMS are accepted as a sensitive diagnostic tool in multiple sclerosis. Recently, TI evoked by TMS has been introduced as a new paradigm to test the function of callosal fibres interconnecting both hand associated motor cortices.Methods-Focal TMS of the motor cortex was performed in 50 patients with early relapsing-remitting multiple sclerosis. Corticospinally mediated (central motor latencies, amplitudes) and transcallosally mediated (onset latency and duration of TI) stimulation effects were investigated.Results-TMS disclosed abnormalities of corticospinally mediated responses in 62% and of TI in 80% of the patients.Conclusion-The assessment of TI allows the discovery of lesions within the periventricular white matter that were not accessible by neurophysiological techniques before. This new paradigm increases the sensitivity of TMS with which to detect central conduction deficits in early multiple sclerosis.