In situ assembly of Mt-HAP drug carrier with pH-responsive sustained release properties
In situ assembly of Mt-HAP drug carrier with pH-responsive sustained release properties
复制标题
原位组装具有pH响应缓释特性的Mt-HAP药物载体
DOI：
10.1088/2053-1591/abb630
复制
发表时间：
2020
影响因子：
2.3
通讯作者：
Jiali Zhang
中科院分区：
文献类型：
--
作者：
Shaohui Wang;Bo Wen;Yingcong Xie;Meiling Zhong;Yongxin Liu;Zanru Guo;Jiali Zhang
Mt-HAP复合材料是通过原位组装技术将层状蒙脱土（Mt）和羟基磷灰石（HAP）纳米颗粒结合而成。阿莫西林（AMX）的载放实验证明，合成的Mt-HAP复合材料具有较高的载药能力和ph响应缓释性能。Mt的AMX负荷为18.5 mg g - 1，而Mt- hap的AMX负荷为49.1 mg g - 1。模拟胃液（pH 1.2）释放实验表明，Mt药物载体在初始2 h内对AMX的释放率较高，但此后，由于HAP在酸性环境下的溶解，Mt-HAP对AMX的释放率（12 h内约65%）高于Mt （12 h内约50%）。然而，Mt- hap在模拟肠液（pH 6.8）中12 h的累积缓释率仅为30%，Mt的释药量仍在49%左右。与Mt@AMX相比，Mt-HAP @AMX的药物释放速度对ph的变化很敏感。研究结果表明，Mt-HAP复合物作为一种药物载体具有很大的潜力，可以实现可控的药物递送。
The Mt-HAP composites were achieved by combining layered montmorillonite (Mt) and hydroxyapatite (HAP) nanoparticles produced by in situ assembly technique. Amoxicillin (AMX) loading and release experiment proved that the synthetic Mt-HAP composites demonstrated high drug loading ability and pH-responsive sustained release property. The AMX load of original Mt was 18.5 mg g−1, while that of Mt-HAP grew to 49.1 mg g−1. Experiments in simulated gastric fluid (pH 1.2) release indicated that Mt drug carrier having a higher release rate of AMX within the initial 2 h. But after that, the drug release rate of AMX from Mt-HAP has a greater value (about 65% over 12 h) than that of Mt (about 50% over 12 h) because of the dissolution of HAP under acidic circumstance. However, the cumulative sustained release rate of Mt-HAP in simulated intestinal fluid (pH 6.8) over 12 h was only 30%, and the drug release amount of Mt was still about 49%. Compared to Mt@AMX, the drug release rate of Mt-HAP @ AMX is sensitive to changes in pH. The findings claimed that the Mt-HAP composite exhibited extreme potential as a drug carrier for controllable drug delivery.