Functional outcomes after chemoradiotherapy of laryngeal and pharyngeal cancers.

Functional outcomes after chemoradiotherapy of laryngeal and pharyngeal cancers.
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DOI:
10.1007/s11912-012-0216-1
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发表时间:
2012-04
影响因子:
4.7
通讯作者:
Lewin, Jan S.
Lewin, Jan S.
中科院分区:
医学2区
文献类型:
--
作者:
Hutcheson, Katherine A.;Lewin, Jan S.

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结合化疗和放疗(放化疗)的器官保存方案越来越多地被用作喉癌和咽癌的主要治疗方法。荟萃分析数据显示,联合治疗的生存获益,但功能后遗症可能显著。吞咽困难被认为是放化疗的一个常见且经常是毁灭性的晚期效应。这篇综述探讨了喉咽癌放化疗后的功能结果,特别强调了吞咽困难。研究主题包括放化疗后吞咽困难的负担、吞咽困难的病理生理学、基线功能、改善长期功能的建议和语音结果。
Organ preservation regimens that combine chemotherapy and radiotherapy (chemoradiotherapy) are increasingly used as the primary treatment of laryngeal and pharyngeal cancers. Meta-analytic data show a survival benefit with combined modality therapy, but the functional sequelae can be significant. Dysphagia is recognized as a common and often devastating late effect of chemoradiotherapy. This review examines functional outcomes after chemoradiotherapy for laryngeal and pharyngeal cancers, with a particular emphasis on dysphagia. Topics examined include the burden of dysphagia after chemoradiation, pathophysiology of dysphagia, baseline functioning, recommendations to improve long-term function, and voice outcomes.
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