SELECTIVE VULNERABILITY IN THE GERBIL HIPPOCAMPUS FOLLOWING TRANSIENT ISCHEMIA
SELECTIVE VULNERABILITY IN THE GERBIL HIPPOCAMPUS FOLLOWING TRANSIENT ISCHEMIA
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DOI：
10.1007/bf00691853
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发表时间：
1984-01-01
影响因子：
12.7
通讯作者：
SANO, K
中科院分区：
文献类型：
--
作者：
KIRINO, T;SANO, K
在短暂的缺血后，蒙古沙鼠出现了不寻常的海马细胞损伤。这种海马的脆弱性进行了研究，在沙鼠缺血3，5，10，20和30分钟，通过双侧闭塞的颈总动脉。它们在不同的存活时间间隔后进行灌注固定，从3小时到7天不等。短暂缺血（5-10分钟）后，90%的动物出现典型的海马损伤。病变存在于整个背侧海马的范围内，而海马外的损伤没有观察到。海马的每一部分都表现出不同类型的细胞对缺血的反应。CA 4神经元呈散在的缺血性改变，CA 2神经元呈反应性改变。CA 1区锥体细胞的死亡过程非常缓慢。缺血3 min大部分不产生海马损伤。长时间缺血（20-30分钟）后，脑损伤的范围和分布有很大变化。沙土鼠短暂缺血模型是研究海马选择性缺血易损性的一个良好、可靠的模型。在不同程度的缺血损伤后，证实了CA 1锥体细胞中的迟发性神经元死亡。短暂缺血后神经元损伤的病理学既不统一也不简单。
Following brief ischemia, the Mongolian gerbil is reported to develop unusual hippocampal cell injury. This hippocampal vulnerability was investigated in gerbils subjected to ischemia for 3, 5, 10, 20 and 30 min by bilateral occlusion of the common carotid arteries. They were perfusion-fixed after varying intervals of survival time ranging from 3 h up to 7 days. Following brief ischemia (5-10 min), .apprx. 90% of the animals developed typical hippocampal damage. The lesion was present throughout the extent of the dorsal hippocampus, whereas damage outside the hippocampus was not observed. Each sector of the hippocampus showed different types of cell reaction to ischemia. Ischemic cell change was seen in scattered CA4 neurons and reactive change was found in CA2. CA1 pyramidal cells developed a strikingly slow cell death process. Ischemia for 3 min did not produce hippocampal lesion in most cases. Following prolonged ischemia (20-30 min), brain injury had a wide variety in its extent and distribution. The gerbil brief ischemia model can serve as an excellent, reliable model to study the long-known hippocampal selective vulnerability to ischemia. Delayed neuronal death in CA1 pyramidal cells was confirmed after varying degrees of ischemic insult. The pathology of neuronal injury following brief ischemia was by no means uniform nor simple.