Transition-metal-catalyzed sequential cross-coupling of bis(iodozincio)methane and -ethane with two different organic halides.
Transition-metal-catalyzed sequential cross-coupling of bis(iodozincio)methane and -ethane with two different organic halides.
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DOI：
10.1002/chem.200500767
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发表时间：
2006-01
期刊：
影响因子：
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通讯作者：
H. Yoshino;N. Toda;Masami Kobata;K. Ukai;K. Oshima;K. Utimoto;S. Matsubara
中科院分区：
文献类型：
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作者：
H. Yoshino;N. Toda;Masami Kobata;K. Ukai;K. Oshima;K. Utimoto;S. Matsubara
由二碘甲烷和锌制备的双（碘锌）甲烷在过渡金属催化剂存在下与有机卤化物反应，得到碘锌亚甲基化化合物;然后与另一种有机卤化物反应形成C-C键。整个过程用一个碳原子连接两个亲电体。双（碘锌）乙烷也可以进行这种转化，产生一个新的立体中心。用手性钯催化剂研究了该立体中心的不对称诱导。
Bis(iodozincio)methane, prepared from diiodomethane and zinc, reacts with an organic halide in the presence of a transition-metal catalyst to give an iodozinciomethylenated compound; this then reacts with another organic halide to form a C--C bond. The overall process connects two electrophiles with one carbon atom. Bis(iodozincio)ethane can also undergo this transformation, yielding a new stereogenic center. The asymmetric induction of this stereogenic center was investigated by using a chiral palladium catalyst.