Lactobacillus GG treatment during pregnancy for the prevention of eczema: a randomized controlled trial
Lactobacillus GG treatment during pregnancy for the prevention of eczema: a randomized controlled trial
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DOI：
10.1111/j.1398-9995.2010.02507.x
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发表时间：
2011-04-01
期刊：
影响因子：
12.4
通讯作者：
Tang, M. L. K.
中科院分区：
文献类型：
--
作者：
Boyle, R. J.;Ismail, I. H.;Tang, M. L. K.
研究背景：在生命早期补充益生菌可能对预防湿疹有效.以前的研究表明，产前管理可能是特别重要的有益effects.Objective：我们研究是否产前治疗与益生菌鼠李糖乳杆菌GG（LGG）可以影响湿疹的风险在infanty.Methods：我们招募了250名孕妇携带婴儿过敏性疾病的高风险的随机对照试验益生菌补充剂（LGG 1.8 × 1010 cfu/天）从妊娠36周，直到分娩。婴儿在第一年进行湿疹或过敏性致敏评估。在一个亚组中进行免疫学研究。检查脐带血树突状细胞和调节性T细胞数量以及TGF β、IL-10、IL-12、IL-13、IFN-γ和TNF α的产生。孕妇母乳检查总伊加，可溶性CD 14和TGF β。结果：产前益生菌治疗与湿疹（34%益生菌，39%安慰剂; RR 0.88; 95%CI 0.63，1.22）或IgE相关湿疹（18%益生菌，19%安慰剂; RR 0.94; 95%CI 0.53，1.68）的风险降低无关。产前益生菌治疗与脐带血免疫标志物的任何变化无关，但与母乳可溶性CD 14和伊加水平降低有关。结论：产前治疗与鼠李糖乳杆菌GG是不足以预防湿疹。如果益生菌对预防湿疹有效，那么治疗的产后成分或可能的替代益生菌菌株是必要的。
P>Background:Probiotic supplementation in early life may be effective for preventing eczema. Previous studies have suggested that prenatal administration may be particularly important for beneficial effects.Objective:We examined whether prenatal treatment with the probiotic Lactobacillus rhamnosus GG (LGG) can influence the risk of eczema during infancy.Methods:We recruited 250 pregnant women carrying infants at high risk of allergic disease to a randomized controlled trial of probiotic supplementation (LGG 1.8 x 1010 cfu/day) from 36 weeks gestation until delivery. Infants were assessed during their first year for eczema or allergic sensitization. Immunological investigations were performed in a subgroup. Umbilical cord blood was examined for dendritic cell and regulatory T cell numbers and production of TGF beta, IL-10, IL-12, IL-13, IFN-gamma and TNF alpha. Maternal breast milk was examined for total IgA, soluble CD14 and TGF beta.Results:Prenatal probiotic treatment was not associated with reduced risk of eczema (34% probiotic, 39% placebo; RR 0.88; 95% CI 0.63, 1.22) or IgE-associated eczema (18% probiotic, 19% placebo; RR 0.94; 95% CI 0.53, 1.68). Prenatal probiotic treatment was not associated with any change in cord blood immune markers, but was associated with decreased breast milk soluble CD14 and IgA levels.Conclusions:Prenatal treatment with Lactobacillus rhamnosus GG was not sufficient for preventing eczema. If probiotics are effective for preventing eczema, then a postnatal component to treatment or possibly an alternative probiotic strain is necessary.