Quantitative study of optic nerve head capillaries in experimental optic disk pallor.
Quantitative study of optic nerve head capillaries in experimental optic disk pallor.
复制标题
实验性视盘苍白中视神经乳头毛细血管的定量研究。
DOI：
10.1016/0002-9394(82)90461-5
复制
发表时间：
1982
影响因子：
4.2
通讯作者：
Addicks,EM
中科院分区：
文献类型：
--
作者：
Quigley,HA;Hohman,RM;Addicks,EM
我们对萎缩（苍白）和正常灵长类视神经乳头的毛细血管数量、面积和直径进行了定量测量。苍白视盘中每平方毫米的毛细血管数量与正常视盘中的毛细血管数量没有显着差异。由于所有神经纤维的损失导致神经头物质减少 50%，因此毛细血管必须萎缩才能维持毛细血管数量和组织体积之间的恒定关系。萎缩性神经乳头中单个毛细血管的平均尺寸比正常小，导致毛细血管所占组织体积的百分比减少超过27%：当通过降低血细胞比容值在正常视盘中模拟毛细血管体积的减少时，不会导致视盘苍白。因此，视盘苍白的发展似乎是视盘边缘神经组织变薄以及随之而来的变化的结果组织成分和光学透明度，而不是视盘毛细血管的损失。
We obtained quantitative measurements of capillary numbers, areas, and diameters in atrophic (pale) and normal primate optic nerve heads. The number of capillaries per square millimeter in pale optic disks was not significantly différent from that in normal optic disks. Because the loss of all nerve fibers leads to a 50% decrease in nerve head substance, capillaries must atrophy to maintain a constant relationship between capillary number and tissue volume. The mean size of individual capillaries in atrophic nerve heads was smaller than normal, leading to a decrease of more than 27% in the percentage of tissue volume occupied by capillaries: When this decrease in capillary volume was mimicked in the normal optic disk by reducing the hematocrit value, optic disk pallor did not result.Hence, the development of optic disk pallor appears to be the result of thinning of the neural tissue of the rim of the optic disk and the consequent change in tissue composition and optical transparency, rather than of a loss of optic disk capillaries.