Predicting genetic loading from symptom patterns in obsessive- compulsive disorder: a latent variable analysis.
Predicting genetic loading from symptom patterns in obsessive- compulsive disorder: a latent variable analysis.
复制标题
从强迫症症状模式预测遗传负荷：潜在变量分析。
DOI：
10.1002/da.20444
复制
发表时间：
2008
影响因子：
7.4
通讯作者：
Murphy,DennisL
中科院分区：
文献类型：
--
作者：
Schooler,Carmi;Revell,AndrewJ;Timpano,KiaraR;Wheaton,Michael;Murphy,DennisL
背景：根据对患有强迫症的同胞对的研究的重复发现，强迫症（OCD）患者的一些症状维度具有家族性和推定的遗传基础。然而，这些症状维度均来自耶鲁布朗强迫量表症状检查表评级的探索性因素分析，该分析基于非经验派生的症状类别，而不是个体症状。方法：在本研究中，我们使用一种新颖的潜在变量混合模型分析来识别有意义的患者亚组。在此之前，对 398 名强迫症先证者的 65 项强迫症症状清单进行了验证性因素分析，得出了五因素解决方案。所有五个症状因素的数据均用于潜在变量混合模型分析，该分析确定了两个统计上独立的强迫症亚群。结果：一组先证者的受强迫症影响的亲属（父母或近亲）的比例显着较高，而另一组的家族性强迫症发病率较低。研究还发现，家族性强迫症患者的强迫症发病年龄较早，强迫症症状更严重，精神科合并症和损伤也更大。结论：特别是如果结果在其他样本中得到验证，这种识别了家族性强迫症患者特征的研究范式应该有助于开展强迫症的全基因组连锁和关联研究，并可能为其他基于症状的其他医学疾病研究提供模型。抑郁与焦虑 25:680–688, 2008。2008 年出版 Wiley-Liss, Inc.
Background:Some symptom dimensions in obsessive‐compulsive disorder (OCD) patients have a familial and putative genetic foundation, based on replicated findings in studies of sib‐pairs with OCD. However, these symptom dimensions are all from exploratory factor analyses of Yale‐Brown Obsessive‐Compulsive Scale Symptom Checklist ratings based on non‐empirically derived symptom categories, rather than individual symptoms.Methods:In this study, we used a novel latent variable mixture model analysis to identify meaningful patient subgroupings. This was preceded by a confirmatory factor analysis of a 65‐item OCD symptom inventory from 398 OCD probands, which yielded a five‐factor solution. Data from all five symptom factors were used in a latent variable mixture model analysis, which identified two statistically separate OCD subpopulations.Results:One group of probands had a significantly higher proportion of OCD‐affected afflicted relatives (parents or close parental relatives), whereas the other group had a less prevalent familial OCD. The group with the more familial OCD was also found to have an earlier age of OCD onset, more severe OCD symptoms, and greater psychiatric comorbidity and impairment.Conclusions:Especially if the results are verified in other samples, this research paradigm, which identified characteristics of individuals with familial OCD, should prove useful in carrying out genome‐wide linkage and association studies of OCD and may provide a model for other symptom‐based studies of additional medical disorders. Depression and Anxiety 25:680–688, 2008. Published 2008 Wiley‐Liss, Inc.