Maintenance of Pregnancy with Subcutaneous Pellets of Progesterone in Ovariectomized Mice.∗
Maintenance of Pregnancy with Subcutaneous Pellets of Progesterone in Ovariectomized Mice.∗
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使用皮下黄体酮颗粒维持卵巢切除小鼠的妊娠。*
DOI：
10.3181/00379727-113-28567
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发表时间：
1963
影响因子：
--
通讯作者：
T. R. Forbes
中科院分区：
文献类型：
--
作者：
L. Rubinstein;T. R. Forbes
CHI和Brown Belt种群的小鼠皮下注射17α-羟孕酮或孕酮颗粒，然后在妊娠的不同阶段切除卵巢。保证胎儿存活至足月所需的颗粒中孕酮的平均日吸收量随着妊娠的进展而减少。17α-羟孕酮微丸对去势小鼠的维持妊娠作用不明显。当发现阴道栓的当天被计为第1天时，未处理的完整CHI小鼠的妊娠持续时间通常为19或20天。在棕带鼠中，通常是20或21天。
Summary Mice of the CHI and Brown Belt stocks received subcutaneous pellets of 17α-hydroxyprogesterone or progesterone and then were ovariectomized at various stages of pregnancy. The average daily absorption of progesterone from the pellets which was required to ensure fetal survival to term diminished as pregnancy progressed. 17α-Hydroxyprogesterone pellets were ineffective in maintaining pregnancy in castrate mice. When the day of finding the vaginal plug was counted as day 1, duration of pregnancy in the intact untreated CHI mouse was usually 19 or 20 days. In the Brown Belt mouse, it was usually 20 or 21 days.