Potency of killed plague vaccines prepared from avirulent Yersinia pestis.
Potency of killed plague vaccines prepared from avirulent Yersinia pestis.
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由无毒鼠疫耶尔森氏菌制备的灭活鼠疫疫苗的效力。
DOI：
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发表时间：
1980
影响因子：
11.1
通讯作者：
D. C. Cavanaugh
中科院分区：
文献类型：
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作者：
J. Williams;P. Altieri;S. Berman;J. Lowenthal;D. C. Cavanaugh
在小鼠效力测试中，由鼠疫耶尔森氏菌无毒株 A1122 和 EV76S 制备的灭活鼠疫疫苗比由灭活鼠疫耶尔森氏菌强毒株 195/P 制备的鼠疫疫苗 (USP) 样品更有效。用无毒力的鼠疫耶尔森氏菌生产疫苗将消除目前生产鼠疫疫苗（USP）所需的大型密封设施的要求。
Killed plague vaccines prepared from avirulent strains A1122 and EV76S of Yersinia pestis were more effective in mouse potency tests than samples of Plague Vaccine, USP, prepared from killed Y. pestis of the virulent strain 195/P. Manufacture of vaccine from avirulent Y. pestis would obviate requirements for the large containment facilities that are currently needed for producing Plague Vaccine, USP.