Local injection of vasopressin reduces the blood loss during cesarean section in placenta previa.
Local injection of vasopressin reduces the blood loss during cesarean section in placenta previa.
复制标题
局部注射加压素可减少前置胎盘剖宫产术中的失血量。
DOI：
10.1111/jog.12356
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Ohmichi M
中科院分区：
文献类型：
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作者：
Kato S;Tanabe A;Kanki K;Suzuki Y;Sano T;Tanaka K;Fujita D;Terai Y;Kamegai H;Ohmichi M
Aim本研究的目的是评估局部注射血管加压素对失血量和继发性影响的并发症在剖宫产术中的前置胎盘patients with placenta previa.Material和MethodsWe回顾性分析了所有诊断为前置胎盘的患者入院的病历。比较了两个连续时期。在周期B期间，59名患者在胎盘分娩后接受了血管加压素溶液（20 mL生理盐水中的4 U）局部注射到胎盘植入部位。在A阶段，50例患者接受剖宫产手术，未注射加压素，并作为对照组进行分析。记录估计的失血量以及手术期间的并发症。此外，血管加压素V1α受体在子宫平滑肌的表达进行了评估，通过免疫组化。ResultsThe平均估计失血量在血管加压素组明显低于对照组。手术并发症无统计学显著差异。血管加压素V1α受体在子宫体下段的平滑肌细胞中高度表达，而催产素受体在子宫体下段的免疫反应性较弱。
AimThe aim of this study was to evaluate the effect of local injection of vasopressin on blood loss and secondary impact on complications during cesarean section in patients with placenta previa.Material and MethodsWe retrospectively reviewed the medical records of all patients diagnosed with placenta previa admitted to our hospital. Two consecutive periods were compared. During period B, 59 patients underwent the local injection of a vasopressin solution (4 U in 20 mL of saline) into the placental implantation site after placental delivery. During period A, 50 patients underwent cesarean section without vasopressin injection, and were analyzed as a control group. The estimated blood loss was recorded, as were the complications during surgery. In addition, the expression of the vasopressin V1α receptor in uterine smooth muscle was evaluated by immunohistochemistry.ResultsThe mean estimated blood loss was significantly lower in the vasopressin group than in the control group. There were no statistically significant differences with surgical complications. The vasopressin V1α receptor was highly expressed in smooth muscle cells in the lower segment of the uterine body, whereas the immunoreactivity for the oxytocin receptor was faint in the lower segment.ConclusionThe local injection of vasopressin into the placental implantation site significantly reduced the blood loss without increasing the morbidity.