“Cobblestone” appearance of the ascending colon.
“Cobblestone” appearance of the ascending colon.
复制标题
升结肠的“鹅卵石”外观。
DOI：
10.1007/s12024-012-9351-0
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Takahito et al.
中科院分区：
文献类型：
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作者：
HAYASHI;Takahito et al.
肠粘膜的“鹅卵石”外观，由溃疡划分炎症性水肿粘膜区域组成，是克罗恩病的一个众所周知的宏观标志。然而，在临床内镜和尸检实践中，遇到这种病变是极其罕见的。克罗恩病被定义为一种慢性、复发性炎症，通常表现在青少年或青壮年，最常见于白种人，女性略占优势（高达1.6:1）[1,2]。克罗恩病的确切病因尚不清楚，尽管大量研究表明多种致病因素，如遗传、感染因子、免疫系统损伤、环境因素（如吸烟、缺乏母乳喂养、饮食因素）和情绪压力[1-3]。克罗恩病可以影响从口腔到肛门的消化道的任何部分，但最常发生在回肠和盲肠（约50%）。相反，在本病例中观察到的局限于结肠的病变，仅在约20%的患者中可见。
Discussion“Cobblestone” appearance of the bowel mucosa, consisting of ulcerations demarcating areas of inflammatory edematous mucosa, is a well known macroscopic hallmark of Crohn’s disease. However, encountering such lesion is extremely rare in both clinical endoscopic as well as autopsy practice. Crohn’s disease is defined as a chronic, relapsing inflammatory condition that usually manifests in adolescents or young adults and is most common among Caucasians, with a slight female predominance (up to 1.6: 1)[1, 2]. The precise cause of Crohn’s disease remains unknown, although numerous studies have suggested a variety of pathogenetic factors such as heredity, infectious agents, impairment of immune systems, environmental factors (eg smoking, lack of breast-feeding, dietary factors) and emotional stress [1–3]. Crohn’s disease can affect any part of the digestive tract from the oral cavity to the anus, but occurs most frequently in the ileum and cecum (about 50%). In contrast, lesions limited to the colon, as observed in our case, are only seen in about 20% of the patients [1].