Sex-specific biomechanics and morphology of the anterior cruciate ligament during skeletal growth in a porcine model.
Sex-specific biomechanics and morphology of the anterior cruciate ligament during skeletal growth in a porcine model.
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DOI：
10.1002/jor.25207
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发表时间：
2022-08
影响因子：
2.8
通讯作者：
Fisher, Matthew B.
中科院分区：
文献类型：
--
作者：
Howe, Danielle;Cone, Stephanie G.;Piedrahita, Jorge A.;Collins, Bruce;Fordham, Lynn A.;Griffith, Emily H.;Spang, Jeffrey T.;Fisher, Matthew B.
儿童前交叉韧带（ACL）损伤呈上升趋势，青春期女性ACL损伤风险高于男性。对未成年患者的研究表明，在青春期开始后，男性和女性之间的ACL大小和关节松弛度存在差异。然而，关于ACL及其前内侧束和后外侧束在儿科人群中的功能数据仍然很少。因此，本研究使用猪模型来研究ACL及其束在整个骨骼生长过程中的性别特异性形态学和生物力学。使用磁共振成像对年龄从青年早期到青春期晚期的雄性和雌性约克郡猪的后肢进行成像，以测量ACL及其束的大小和方向，然后使用机器人测试系统在前后抽屉下进行生物力学测试。在两种性别的骨骼生长过程中，关节松弛度降低（p<0.001），而关节僵硬度增加（p<0.001）。ACL是抵抗胫骨前负荷的主要稳定器，而前内侧束的功能作用随着年龄的增长而增加（p<0.001），男性的增加更早。在青春期，男性ACL和后外侧束横截面积以及ACL和前内侧束长度大于女性（所有p<0.01），而ACL和束矢状角在性别之间保持相似。此外，在骨骼生长过程中，原位ACL刚度与横截面积回归具有显著性（男性r2=0.75，p<0.001，女性r2=0.64，p<0.001），但在年龄组内不具有显著性。这项研究对年龄和性别特异性手术干预策略有影响，并建议需要进行人体研究。
Pediatric anterior cruciate ligament (ACL) injuries are on the rise, and females experience higher ACL injury risk than males during adolescence. Studies in skeletally immature patients indicate differences in ACL size and joint laxity between males and females after the onset of adolescence. However, functional data regarding the ACL and its anteromedial and posterolateral bundles in the pediatric population remain rare. Therefore, this study uses a porcine model to investigate the sex-specific morphology and biomechanics of the ACL and its bundles throughout skeletal growth. Hind limbs from male and female Yorkshire pigs aged early youth to late adolescence were imaged using magnetic resonance imaging to measure the size and orientation of the ACL and its bundles, then biomechanically tested under anterior-posterior drawer using a robotic testing system. Joint laxity decreased (p<0.001) while joint stiffness increased (p<0.001) throughout skeletal growth in both sexes. The ACL was the primary stabilizer against anterior tibial loading, while the functional role of the anteromedial bundle increased with age (p<0.001), with an earlier increase in males. ACL and posterolateral bundle cross-sectional area and ACL and anteromedial bundle length were larger in males than females during adolescence (p<0.01 for all), while ACL and bundle sagittal angle remained similar between sexes. Additionally, in situ ACL stiffness versus cross-sectional area regressions were significant across skeletal growth (r2=0.75, p<0.001 in males and r2=0.64, p<0.001 in females), but not within age groups. This study has implications for age and sex-specific surgical intervention strategies and suggests the need for human studies.
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影响因子：
3.3
作者：
Herzog MM;Marshall SW;Lund JL;Pate V;Mack CD;Spang JT
通讯作者：
Spang JT
影响因子：
19.7
作者：
Kim, Hee Kyung;Laor, Tal;Dardzinski, Bernard J.
通讯作者：
Dardzinski, Bernard J.
影响因子：
4.2
作者：
Kiapour, Ata M.;Fleming, Braden C.;Murray, Martha M.
通讯作者：
Murray, Martha M.
影响因子：
2.4
作者：
Imhauser, Carl W.;Kent, Robert N., III;Pearle, Andrew D.
通讯作者：
Pearle, Andrew D.
DOI：
10.1249/mss.0000000000000806
发表时间：
2016-04-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Gray, Aaron M.;Gugala, Zbigniew;Baillargeon, Jacques G.
通讯作者：
Baillargeon, Jacques G.