Enzyme and proton-activated prodrugs for a selective cancer therapy.
Enzyme and proton-activated prodrugs for a selective cancer therapy.
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用于选择性癌症治疗的酶和质子激活前药。
DOI：
10.2174/1381612033454072
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发表时间：
2003
影响因子：
3.1
通讯作者：
T. Feuerstein
中科院分区：
文献类型：
--
作者：
L. Tietze;T. Feuerstein
本文综述了两种选择性抗癌治疗的方法，这两种方法是基于特异性切割专门设计的无毒前药，通过靶向肿瘤相关抗原的抗体-酶偶联物或通过酸催化水解的前药释放细胞毒性化合物，由于在高血糖条件下恶性组织中水合氢离子浓度增加。本文描述了前药的设计、合成和生物学测试。
This review is a survey of two approaches for a selective anticancer therapy that are based on a specific cleavage of specially designed non-toxic prodrugs with the liberation of a cytotoxic compound either by antibody-enzyme conjugates targeted to tumor-associated antigens or by acid-catalyzed hydrolysis of the prodrugs due to the increased concentration of hydronium ions in malignant tissue under hyperglycemic conditions. Herein, the design, synthesis and the biological testing of prodrugs are described.