Reward Sensitivity, Cognitive Response Style, and Inflammatory Response to an Acute Stressor in Adolescents.
Reward Sensitivity, Cognitive Response Style, and Inflammatory Response to an Acute Stressor in Adolescents.
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青少年对急性应激源的奖励敏感性、认知反应方式和炎症反应。
DOI：
10.1007/s10964-020-01216-y
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发表时间：
2020
影响因子：
4.9
通讯作者：
Alloy,LaurenB
中科院分区：
文献类型：
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作者：
Moriarity,DanielP;Ng,Tommy;Curley,ErinE;AnneMcArthur,Brae;Ellman,LaurenM;Coe,ChristopherL;Abramson,LynY;Alloy,LaurenB
炎症作为压力和许多负面结果之间的生物调节剂正在获得越来越多的支持，这些负面结果会增加青春期的风险（例如情绪障碍）。因此，一个重要的研究方向是评估情绪精神病理学的危险因素是否也与这一发育时期对压力的炎症反应增强有关。相互作用预测情绪精神病理学的两个重要风险因素是奖励敏感性和持久的认知反应方式，这也与炎症蛋白升高有关。这些因素可能通过协同放大应激反应来影响炎症。 99 名晚期青少年（Mage= 18.3 岁，范围 = 15.6–21.9 岁）完成了奖励敏感性、认知反应风格以及改良特里尔社会压力任务之前和之后 60 分钟的抽血测量，以确定炎症水平。更高的奖励驱动与更持久的反应风格比率（相对于分心的沉思+解决问题）相互作用，预测白细胞介素6（一种促炎蛋白）的更大增加。后续分析发现，奖励驱动与比率的所有三个组成部分相互作用，以预测 IL-6 的变化。因此，这些结果表明，高奖励驱动和持久的认知反应方式与青少年对社会压力的炎症反应增加有关，这是将这些危险因素与这一发育时期的情绪精神病理学联系起来的潜在生理机制。
Inflammation is gaining support as a biological mediator between stress and many negative outcomes that have heightened risk during adolescence (e.g., mood disorders). Thus, an important line of inquiry is evaluating whether risk factors for mood psychopathology also are associated with heightened inflammatory responses to stress during this developmental period. Two prominent risk factors that interact to predict mood psychopathology are reward sensitivity and perseverative cognitive response styles, which also have been associated with heightened inflammatory proteins. These factors could influence inflammation by synergistically amplifying stress reactivity. Ninety-nine late adolescents (Mage= 18.3 years, range = 15.6–21.9 years) completed measures of reward sensitivity, cognitive response style, and blood draws before and 60-min after a modified Trier Social Stress Task to determine levels of inflammation. Higher reward drive interacted with more perseverative response style ratios (rumination relative to distraction + problem-solving) to predict larger increases in interleukin-6 (a proinflammatory protein). Follow-up analyses found that reward drive interacted with all three components of the ratio to predict change in interleukin-6. Thus, these results suggest that high reward drive and perseverative cognitive response styles are associated with increased inflammatory response to social stress in adolescents, a potential physiological mechanism linking these risk factors to mood psychopathology during this developmental period.