Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell
Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell
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DOI：
10.1038/sj.leu.2405019
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发表时间：
2008-02-01
期刊：
影响因子：
11.4
通讯作者：
Deckert, M.
中科院分区：
文献类型：
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作者：
Montesinos-Rongen, M.;Brunn, A.;Deckert, M.
为探讨原发性中枢神经系统淋巴瘤（PCNSL）的分子起源，应用基因芯片技术对21例免疫功能正常的PCNSL进行了研究。PCNSL与各种正常和肿瘤性B细胞亚群的转录谱的比较表明PCNSL（i）显示与晚期生发中心B细胞最密切相关的基因表达模式，（ii）显示与系统性弥漫性大B细胞淋巴瘤（DLBCL）相似的基因表达谱，和（iii）部分归因于活化的B细胞样（ABC）或生发中心B细胞样（GCB），DLBCL的亚型。
To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated PCNSL (i) to display gene expression patterns most closely related to late germinal center B cells, (ii) to display a gene expression profile similar to systemic diffuse large B-cell lymphomas (DLBCLs) and (iii) to be in part assigned to the activated B-cell-like (ABC) or the germinal center B-cell-like (GCB) subtype of DLBCL.