Recent progress on nuclear receptor RORγ modulators
Recent progress on nuclear receptor RORγ modulators
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DOI：
10.1016/j.bmcl.2016.08.012
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发表时间：
2016-09-15
影响因子：
2.7
通讯作者：
Crawford, James J.
中科院分区：
文献类型：
--
作者：
Cyr, Patrick;Bronner, Sarah M.;Crawford, James J.
The retinoic acid receptor-related orphan receptor ROR gamma plays key roles in the development and differentiation of T(H)17 cells, and thus in IL-17 expression, thymocyte development and regulation of metabolism. With the recent progression into phase 2 clinical trials of both oral and topically administered inverse agonists, and with others close behind, there is significant interest in the discovery of ROR gamma modulators. This digest covers key developments around ROR gamma agonists, antagonists and inverse agonists; orthosteric and allosteric binders; and aims to summarize the available information concerning the potential utility of ROR gamma modulators. (C) 2016 Elsevier Ltd. All rights reserved.
