Outside-in Signaling by Adventitial Fibroblasts.
Outside-in Signaling by Adventitial Fibroblasts.
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DOI：
10.1161/atvbaha.120.315466
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Miller FJ Jr
中科院分区：
文献类型：
--
作者：
Schickling BM;Miller FJ Jr
不久前，血管外皮层被认为是由成纤维细胞和血管周围神经组成的普通结缔组织。过去20年的一些观察改变了这种误解。内皮型一氧化氮合酶在内皮外成纤维细胞中的过度表达挽救了激动剂介导的无内皮动脉血管舒张，而在内皮外层中产生的活性氧灭活了内皮源性一氧化氮。1,2这些数据为外膜释放的物质可以改变血管功能提供了直接证据。外膜现在被认为是血管壁最复杂的一层，不仅由成纤维细胞和神经组成，还包括炎症细胞、微血管、淋巴管和不同祖细胞亚群之间的动态相互作用。
Not long ago, the blood vessel’s adventitial layer was considered nondescript connective tissue comprised of fibroblasts and perivascular nerves. Several observations over the past 20 years have changed this misconception. The overexpression of endothelial nitric oxide synthase in adventitial fibroblasts rescued agonist-mediated vasodilation in arteries without endothelium and reactive oxygen species generated in the adventitial layer inactivated endothelium-derived nitric oxide. 1, 2 These data provided direct evidence that substances released from the adventitia could modify vascular function. The adventitia is now recognized as the most complex layer of the vessel wall, comprised not only of fibroblasts and nerves but of dynamic interactions between inflammatory cells, microvessels, lymphatics, and distinct subpopulations of progenitor cells.