Novel families of vacuolar amino acid transporters
Novel families of vacuolar amino acid transporters
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DOI：
10.1002/iub.92
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发表时间：
2008-08
期刊：
影响因子：
4.6
通讯作者：
T. Sekito;Y. Fujiki;Y. Ohsumi;Y. Kakinuma
中科院分区：
文献类型：
--
作者：
T. Sekito;Y. Fujiki;Y. Ohsumi;Y. Kakinuma
氨基酸在微生物和植物的液泡中被分隔开来。在酿酒酵母中，碱性氨基酸优先积累到液泡中，而酸性氨基酸几乎不在液泡中。这表明选择性机械在液泡膜上起作用。最近在对酿酒酵母的研究中发现了氨基酸/生长素渗透酶家族的成员和参与氨基酸液泡区域化的主要促进剂超家族。在植物和哺乳动物的基因组中也发现了这些转运蛋白的同源基因。现在可以讨论氮饥饿反应的生理意义了。©2008 IUBMB IUBMB生活，60(8)：519-525,2008
Amino acids are compartmentalized in the vacuoles of microorganisms and plants. In Saccharomyces cerevisiae, basic amino acids accumulate preferentially into vacuoles but acidic amino acids are almost excluded from them. This indicates that selective machineries operate at the vacuolar membrane. The members of the amino acid/auxin permease family and the major facilitator superfamily involved in the vacuolar compartmentalization of amino acids have been recently identified in studies using S. cerevisiae. Homologous genes for these transporters are also found in plant and mammalian genomes. The physiological significance in response to nitrogen starvation can now be discussed. © 2008 IUBMB IUBMB Life, 60(8): 519–525, 2008