Olfactory cortex and Olfactory bulb volume alterations in patients with post-infectious Olfactory loss
Olfactory cortex and Olfactory bulb volume alterations in patients with post-infectious Olfactory loss
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DOI：
10.1007/s11682-017-9807-7
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发表时间：
2018-10-01
影响因子：
3.2
通讯作者：
Wei, Yongxiang
中科院分区：
文献类型：
--
作者：
Yao, Linyin;Yi, Xiaoli;Wei, Yongxiang
上呼吸道感染（URI）是嗅觉丧失的最常见病因之一。先前的研究表明，与正常对照相比，感染后嗅觉丧失（PIOL）患者的嗅球（OB）体积和嗅沟（OS）深度均减少。我们研究的目的是观察 PIOL 患者中枢嗅觉通路的变化。使用 3T 扫描仪采集 19 名 PIOL 患者和 19 名年龄和性别匹配的对照受试者的 T1 加权磁共振图像。基于体素的形态测量 (VBM) 是在 Matlab 环境中使用 VBM8 工具箱和 SPM8 进行的。我们还分析了冠状 T2 加权图像中的 OB 体积。全脑分析显示患者组右眶额皮质（OFC）灰质体积显着减少。对感兴趣区域的进一步分析显示，这些患者的右侧 OFC 灰质体积以及 OB 体积与嗅觉丧失持续时间之间存在显着负相关（r = -0.566 和 r = -0.535 均 P
Upper respiratory tract infection (URI) is one of the most common etiology of olfactory loss. Previous studies demonstrated that both olfactory bulb (OB) volume and sulcus (OS) depth decreased in patients with post-infectious olfactory loss (PIOL) compared to normal controls. The aim of our study was to observe alterations of central olfactory pathways in patients with PIOL. T1 weighted magnetic resonance images were acquired in 19 PIOL patients and 19 age- and sex-matched control subjects on a 3T scanner. Voxel-based morphometry (VBM) was performed using VBM8 toolbox and SPM8 in a Matlab environment. We also analyzed OB volume in coronal T2-weighted images. Whole-brain analysis revealed a significant gray matter volume loss in the right orbitofrontal cortex (OFC) in patients group. Further analysis with region of interest exhibited a significant negative correlation between gray matter volume in right OFC as well as OB volume and the duration of olfactory loss in these patients (r = -0.566 and r = -0.535 both P