The prognostic significance of p63 cytoplasmic expression in colorectal cancer An immunohistochemical study
The prognostic significance of p63 cytoplasmic expression in colorectal cancer An immunohistochemical study
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DOI：
10.15537/smj.2019.5.24162
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发表时间：
2019-05-01
影响因子：
1.6
通讯作者：
Khalil, Amal A.
中科院分区：
文献类型：
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作者：
Albasri, Abdulkader M.;Elkablawy, Mohammed A.;Khalil, Amal A.
目的：评估沙特结直肠癌（CRC）患者中p63表达模式，并将其与临床病理参数及其在癌发生和预后中的作用相关联。通过免疫组织化学分析了2006年1月至2017年12月期间在麦地那三级护理医院病理科诊断为CRC的324名连续沙特患者的存档肿瘤样本的p63表达，结果：P63蛋白在正常粘膜中无过表达，而在腺瘤中有12.5%的P63蛋白过表达。在结直肠癌中，24.1%的病例中p63高表达。p63表达与性别、肿瘤部位、肿瘤大小及肿瘤组织分化程度无明显相关性。然而，p63高表达显示与年龄显著相关（p=0.035），肿瘤类型（p=0.004），美国癌症联合委员会分期（p=0.046），淋巴结转移（p=0.006）、淋巴管浸润（p=0.006）、远处转移（p=0.049）、Ki 67高表达（p=0.000）和K-ras高表达（p=0.002）。Kaplan-Meier分析显示p63过表达组生存期较短（p
Objectives: To evaluate p63 expression pattern in Saudi colorectal cancer (CRC) patients and correlate that with clinicopathological parameters and its role in carcinogenesis and prognosis.Methods: Archival tumor samples were analyzed by immunohistochemistry for p63 expression in 324 consecutive Saudi patients diagnosed with CRC between January 2006 and December 2017 at the Pathology Department of a tertiary care Hospital, Madinah, Saudi Arabia.Results: P63 over-expression was absent in normal mucosa, while 12.5% cases of adenoma showed its overexpression. In CRC, p63 expression was high in 24.1% of cases. There were no significant correlations between p63 expression and gender, tumor location, tumor size, and tumor histologic differentiation. However, high p63 expression revealed a significant correlation with age (p=0.035), tumor type (p=0.004), American Joint Committee on Cancer stage (p=0.046), lymph node metastasis (p=0.006), lymphovascular invasion (p=0.006), distant metastasis (p=0.049) high Ki67 expression (p=0.000) and K-ras expression (p=0.002). The Kaplan-Meier analysis revealed a shorter period of survival with p63 over-expression (p