Pathology of Meniere's disease.
Pathology of Meniere's disease.
复制标题
梅尼埃病的病理学。
DOI：
10.1177/00034894840930s406
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Paparella,MM
中科院分区：
文献类型：
--
作者：
Paparella,MM
从最近的调查结果审查，梅尼埃病的病理描述和相关的临床体征。由于梅尼埃病只能在人类中发现，因此评估其自然史非常重要。最近对500名患者的调查表明，三个主要症状是前庭，听觉和听觉压力。梅尼埃病（特发性）与梅尼埃综合征（有可能原因的症状）不同，后者约占患者的四分之一。非典型形式包括前庭和耳蜗梅尼埃病。最近回顾我们的颞骨收集和详细的研究文献中描述的134个颞骨的病理条件，揭示了特征性的病理结果。有明确梅尼埃病史的患者在死亡时可能表现出很少或没有内淋巴积水。然而，下峡部水肿仍然是梅尼埃病最重要的病理相关性。根据这些发现，疾病的发病机制（内淋巴吸收不良）和症状的病理生理（物理和化学）进行了讨论。
From review of recent findings, the pathology of Meniere's disease is described and correlated with clinical signs. Since Meniere's disease can be seen only in humans, assessing its natural history is important. A recent survey of 500 patients demonstrated the three major symptoms to be vestibular, auditory, and aural pressure. Meniere's disease (idiopathic) is distinguished from Meniere's syndrome (symptoms with likely cause), which accounted for approximately one fourth of the patients. Atypical forms include vestibular and cochlear Meniere's disease. A recent review of our temporal bone collection and detailed study of the pathological conditions of 134 temporal bones described in the literature revealed characteristic pathological findings. Patients with clear-cut histories of Meniere's disease may demonstrate little or no endolymphatic hydrops at death. Nevertheless, hydrops of the pars inferior remains the most significant pathological correlate of Meniere's disease. On the basis of these findings, the pathogenesis of the disease (malabsorption of endolymph) and the pathophysiology of the symptoms (physical and chemical) are discussed.