Reduced energy utilization in the brain is a feature of an animal model of fatigue
Reduced energy utilization in the brain is a feature of an animal model of fatigue
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DOI：
10.1080/00207450701242974
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发表时间：
2008-01-01
影响因子：
2.2
通讯作者：
Watanabe, Yasuyoshi
中科院分区：
文献类型：
--
作者：
Tanaka, Masaaki;Watanabe, Yasuyoshi
最近，作者建立了疲劳的动物模型。疲劳的动物显示其脑中2-[F-18]氟-2-脱氧-D-葡萄糖摄取减少，尽管其血糖水平与对照动物没有差异。为了进一步澄清，该研究测量了疲劳大鼠和对照大鼠大脑中的局部脑血流量，ATP水平和线粒体产生ATP的能力。疲劳的动物表现出几乎相等的局部脑血流量，显著更高的ATP水平，以及几乎相等的线粒体产生ATP的能力。这些数据表明，大脑能量利用率下降是疲劳的一个特征。
Recently, the authors established an animal model of fatigue. The fatigued animals showed reduced 2-[F-18]fluoro-2-deoxy-D-glucose uptake in their brain, although their blood glucose level did not differ from that of the control animals. For further clarification, the study measured regional cerebral blood flow, ATP level, and the ability of mitochondria to produce ATP in the brain of the fatigued and control rats. The fatigued animals showed almost equal regional cerebral blood flow, a significantly higher ATP level, and almost equal mitochondria ability to produce ATP. These data suggest that decreased energy utilization in the brain is a feature of fatigue.