Risk of Venous Thromboembolism in Hospitalized Patients with Acute Ischemic Stroke Versus Other Neurological Conditions
Risk of Venous Thromboembolism in Hospitalized Patients with Acute Ischemic Stroke Versus Other Neurological Conditions
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DOI：
10.1016/j.jstrokecerebrovasdis.2021.106077
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发表时间：
2021-09-06
影响因子：
2.5
通讯作者：
Leira, Enrique C.
中科院分区：
文献类型：
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作者：
Garg, Aayushi;Dhanesha, Nirav;Leira, Enrique C.
背景：急性缺血性卒中(AIS)后静脉血栓栓塞症(VTE)风险增加的机制尚不清楚。在这项研究中，我们旨在评估由于AIS而住院的VTE与由于非血管神经疾病而导致的VTE的风险。我们还旨在评估AIS住院患者中静脉血栓栓塞症风险与静脉溶栓治疗(RtPA)之间的任何潜在联系。材料和方法：在这项病例对照研究中，数据来自2016-2018年全国住院患者样本。使用倾向分数匹配来调整两组之间的基线差异。采用Logistic回归分析比较发生VTE的危险性。结果：我们确定了1,541,685例因AIS住院的患者和1,453,520例因非血管神经疾病住院的患者作为对照。经过倾向性评分匹配后，获得640,560例AIS患者和相应的匹配良好的对照组。与对照组相比，因AIS而住院的患者发生VTE的几率更高[优势比(OR)1.50，95%可信区间(CI)1.40~1.60，P
Background: The mechanism of increased risk of venous thromboembolism (VTE) after acute ischemic stroke (AIS) is unclear. In this study, we aimed to evaluate the risk of VTE in hospitalizations due to AIS as compared to those due to non-vascular neurological conditions. We also aimed to assess any potential association between VTE risk and the use of intravenous thrombolysis (rtPA) among hospitalizations with AIS. Materials and methods: In this case-control study, data were obtained from the Nationwide Inpatient Sample 2016-2018. Propensity score matching was used to adjust for the baseline differences between the groups. Logistic regression analy-sis was used to compare the risk of VTE. Results: We identified 1,541,685 hospital-izations due to AIS and 1,453,520 hospitalizations due to non-vascular neurological diagnoses that served as controls. After propensity score matching, 640,560 cases with AIS and corresponding well-matched controls were obtained. Hospitalizations due to AIS had higher odds of VTE as compared to the controls [odds ratio (OR) 1.50, 95% confidence interval (CI) 1.40-1.60, P