HPLC-Assisted Automated Oligosaccharide Synthesis: Implementation of the Autosampler as a Mode of the Reagent Delivery.
HPLC-Assisted Automated Oligosaccharide Synthesis: Implementation of the Autosampler as a Mode of the Reagent Delivery.
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DOI：
10.1021/acs.joc.6b01439
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发表时间：
2016-10-07
期刊：
影响因子：
--
通讯作者：
Demchenko AV
中科院分区：
文献类型：
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作者：
Pistorio SG;Nigudkar SS;Stine KJ;Demchenko AV
开发一个有用的方法，简单，可扩展的，和变革性的自动化的寡糖合成，很容易与现有的方法接口的报告。现在可以使用可访问的设备进行自动化合成，其中反应物和试剂由泵或自动进样器输送，并且反应可以由UV检测器监测。基于HPLC的自动化平台易于设置并适应不同的系统和目标。
The development of a useful methodology for simple, scalable, and transformative automation of oligosaccharide synthesis that easily interfaces with existing methods is reported. The automated synthesis can now be performed using accessible equipment where the reactants and reagents are delivered by the pump or the autosampler and the reactions can be monitored by the UV detector. The HPLC-based platform for automation is easy to setup and adapt to different systems and targets.