Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
复制标题
DOI：
10.1038/nn1678
复制
发表时间：
2006-05-01
影响因子：
25
通讯作者：
Isaac, JTR
中科院分区：
文献类型：
--
作者：
Plant, K;Pelkey, KA;Isaac, JTR
出生后的海马神经元突触通常被认为在生理条件下仅表达钙不可渗透的（CI），含GluR 2的AMPAR。然而，在这里，我们证明，在CA 1海马锥体神经元的长时程增强（LTP）导致快速纳入GluR 2 lackingcalcium-permeable（CP）AMPAR：CP-AMPAR是暂时的，被取代的GluR 2含有AMPAR类似LTP诱导后25分钟。因此，CP-AMPAR在LTP期间在CA 1锥体细胞突触处生理性表达，并且可能是LTP巩固所需的。
Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lackingcalcium-permeable (CP)AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs similar to 25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.