Correlation of CpG island methylator phenotype with poor prognosis in hepatocellular carcinoma
Correlation of CpG island methylator phenotype with poor prognosis in hepatocellular carcinoma
复制标题
CpG岛甲基化表型与肝细胞癌不良预后的相关性
DOI：
10.1016/j.yexmp.2009.10.008
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发表时间：
2010-02-01
影响因子：
3.6
通讯作者：
Wei, Lixin
中科院分区：
文献类型：
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作者：
Cheng, Yue;Zhang, Changsong;Wei, Lixin
CpG岛甲基化表型(CIMP)是肝细胞癌发生发展的重要机制之一，其中多个基因同时甲基化。采用甲基化特异性聚合酶链式反应技术，检测了60例肝细胞癌、60例配对非肿瘤组织和6例正常肝组织中10个基因的启动子甲基化状态。结果表明，肝细胞癌与非肿瘤组织的平均甲基化基因数差异有统计学意义(P
CpG island methylator phenotype (CIMP), in which multiple genes are concurrently methylated, is an important mechanism in hepatocellular carcinoma development. We determined a hypermethylation profile in hepatocellular carcinoma (HCC).We examined the promoter methylation status of 10 genes in 60 cases of hepatocellular carcinoma (HCC), 60 cases of paired non-tumor tissues, and 6 cases of normal tissues by methylation-specific PCR.The average methylated gene numbers were significantly different between HCC and nontumor tissues (p