Physiological roles of PKB/Akt isoforms in development and disease
Physiological roles of PKB/Akt isoforms in development and disease
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DOI：
10.1042/bst0350231
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发表时间：
2007-04-01
影响因子：
3.9
通讯作者：
Hemmings, B. A.
中科院分区：
文献类型：
--
作者：
Dummler, B.;Hemmings, B. A.
PKB（蛋白激酶B，也称为Akt）是丝氨酸/苏氨酸蛋白激酶，其在各种信号级联中是重要的，并且作为活化的磷酸肌醇3-激酶下游的主要信号转导物。在哺乳动物细胞中有三种密切相关的PKB亚型，PKBa（Akt 1），POP（Akt 2）和PKBy（Akt 3），本文综述了我们对这些亚型在脂肪细胞分化，葡萄糖稳态和肿瘤发展的调节中的功能的最新进展。
PKB (protein kinase B, also known as Akt) is a serine/threonine protein kinase that is important in various signalling cascades and acts as a major signal transducer downstream of activated phosphoinositide 3-kinase. There are three closely related isoforms of PKB in mammalian cells, PKBa (Akt1), POP (Akt2) and PKBy (Akt3), and this review discusses recent advances in our understanding of the functions of these isoforms in the regulation of adipocyte differentiation, glucose homoeostasis and tumour development.